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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A GENERAL A(3)-COUPLING REACTION BASED ON FUNCTIONALIZED ALKYNES

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Author(s):
Wendler, Edison P. [1] ; Dos Santos, Alcindo A. [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Química Nova; v. 36, n. 8, p. 1155+, 2013.
Web of Science Citations: 2
Abstract

A range of hydroxypropargylpiperidones were efficiently obtained by a one-pot three-component coupling reaction of aldehydes, alkynols, and a primary amine equivalent (4-piperidone hydrochloride hydrate) in ethyl acetate using copper(I) chloride as a catalyst. The developed protocol proved to be equally efficient using a range of aliphatic aldehydes, including paraformaldehyde, and using protected and unprotected alkynols. (AU)

FAPESP's process: 11/11613-8 - A3-coupling reactions on the synthesis of bioactive nitrogen containing compounds
Grantee:Alcindo Aparecido dos Santos
Support Opportunities: Regular Research Grants