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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of vascular endothelian growth factor-C does not predict occult lymphnode metastasis in early oral squamous cell carcinoma

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Author(s):
Faustino, S. E. S. [1] ; Oliveira, D. T. [1] ; Nonogaki, S. [2] ; Landman, G. [3] ; Carvalho, A. L. [4] ; Kowalski, L. P. [4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, Bauru - Brazil
[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil
[3] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil
[4] AC Camargo Canc Hosp, Dept Otorhinolaryngol Head & Neck Surg, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: International Journal of Oral and Maxillofacial Surgery; v. 37, n. 4, p. 372-378, APR 2008.
Web of Science Citations: 16
Abstract

Strong vascular endothelial growth factor-C (VEGF-C) expression has been correlated to occurrence of lymph-node metastases in patients with oral squamous cell carcinoma (OSCC). The incidence of occult lymph-node metastasis remains a decisive factor in the prognosis of patients with early OSCC. The aim of this study was to evaluate VEGF-C expression as a predictor of occult lymph-node metastasis in OSCC. Eighty-seven patients with primary OSCC arising in the tongue or floor of mouth, clinically T1N0M0 or T2N0M0, with (pN+) and without (pN0) occult lymph-node metastases were analyzed for VEGF-C expression by malignant cells. Occult lymph-node metastases (pN+) were detected in 22% of the 64 patients who were submitted to elective neck dissection. No statistically significant difference was found between OSCC with and without occult lymph-node metastasis in regard to VEGF-C immunoexpression by malignant cells and clinicopathologic features. Independently of VEGF-C expression, lymph-node metastasis (PN+) was the most significant prognostic factor for overall survival of patients with OSCC (p = 0.030). These findings indicate that isolated VEGF-C expression by malignant cells is not of predictive value for occult lymph-node metastasis in the early stages of OSCC. (AU)

FAPESP's process: 05/04577-4 - Influence of VEGF-C and lymphatic vessel density on regional metastasis and prognosis of patients with oral squamous cell carcinoma
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants