Clinicopathological factors and immunohistochemical expression of potencial predictive markers for cervical metastasis in early (T1-T2) squamous cell carcinoma of the tongue and floor of the mouth

• Grant number: 11/03507-3
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2012
• Effective date (End): May 19, 2014
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal researcher: Luiz Paulo Kowalski
• Grantee: Natalie Kelner de Queiroz
• Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil

Abstract

Oral squamous cell carcinoma (SCC) is considered to be the most frequent cancer in the head and neck region. Despite advances in diagnosis and treatment, the patients prognosis with oral SCC remains largely unchanged for decades. The lymph node involvement is the most important factor in determining the prognosis of these patients. The incidence of occult metastasis in cervical lymph nodes of patients with oral SCC is high, accounting for 23.1% to 42% in clinical stages I and II, respectively, probably due to the extensive vascularization. This occurence remains a strong argument for the indication of elective neck dissection. This study is designed to evaluate the clinical and pathological features and immunohistochemical expression of biomarkers potentially associated with risk of lymph node metastasis in early squamous cell carcinomas (T1-T2) of the tongue and mouth floor. The identification of these molecules that are associated with the metastatic process may be important for the exploration of new methods for early diagnosis, prognostic evaluation and standardization of new therapeutic strategies. Thus, the careful determination of these patients with oral SCC and an increased risk of developing regional metastasis based on tumor biological knowledge can be used to select a suitable and safe indication of elective neck dissection.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KELNER, NATALIE; RODRIGUES, PRISCILA CAMPIONI; BUFALINO, ANDREIA; FONSECA, FELIPE PAIVA; DOS SANTOS-SILVA, ALAN ROGER; COSTA MIGUEL, MARCIA CRISTINA; LOPES PINTO, CLOVIS ANTONIO; PAES LEME, ADRIANA FRANCO; GRANER, EDGARD; SALO, TUULA; KOWALSKI, LUIZ PAULO; COLETTA, RICARDO D. Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 37, n. 4, p. 479-486, APR 2015. Web of Science Citations: 25.

KELNER, NATALIE; VARTANIAN, JOSE GUILHERME; LOPES PINTO, CLOVIS ANTONIO; COUTINHO-CAMILLO, CLAUDIA MALHEIROS; KOWALSKI, LUIZ PAULO. Does elective neck dissection in T1/T2 carcinoma of the oral tongue and floor of the mouth influence recurrence and survival rates?. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, v. 52, n. 7, p. 590-597, SEP 2014. Web of Science Citations: 12.