Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior

Author(s)

Daniela F. Gusmão ^[1] ; Dirce M. Estork ^{[2, 3]} ; Mateus L.B. Paciencia ^[4] ; Ingrit E.C. Díaz ^[4] ; Edna F.S. Montero ^[6] ; Antonio Drauzio Varella ^{[4, 7]} ; Luiz Fernando Lima Reis ^[7] ; Riad N. Younes ^[4] ; Ivana B. Suffredini ^{[2, 3, 4]} ; Maria M. Bernardi ^{[2, 3]}

Affiliation

^[1] Universidade Paulista. Programa de Pós-graduação em Patologia Ambiental e Experimental e Programa de Pós-graduação em Odontologia - Brasil

^[2] Univ Paulista, Programa Posgrad Patol Ambiental & Expt, Sao Paulo - Brazil

^[3] Univ Paulista, Programa Posgrad Odontol, Sao Paulo - Brazil

^[4] Univ Paulista, Nucleo Pesquisas Biodiversidade, Sao Paulo - Brazil

^[5] Universidade Paulista. Núcleo de Pesquisas em Biodiversidade - Brasil

^[6] Univ Sao Paulo, Fac Med, LIM 62, Sao Paulo - Brazil

^[7] Inst Ensino & Pesquisa Hosp Sirio Libanes, Sao Paulo - Brazil

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 6, p. 903-912, 2013-12-00.

Abstract

The organic extract EB689, obtained from the stem of Abarema auriculata (Benth.) Barneby & J.W.Grimes, Fabaceae, commonly known as "saboeiro-ferro", was chemically studied, as well as its influence over behavioral effects such as locomotion, emotionality and anxiety, after intra-peritonial administration were assessed. The open-field and elevated-plus maze were used in experiments divided into two stages. The first stage aimed for the identification of the main effects over behavior using a reduced number of animals against half-fold diluted doses of EB689. The same variables were also tested in a second stage of the experiment using the non-lethal intra-peritoneal dose of 4.8 mg/kg in a larger number of animals. It was observed that EB689 clearly decreased locomotion, which was probably caused by internal hemorrhage causing hypovolemic shock. Although it is the first time lupeol and eucryphin are described in A. auriculata, it is still not clear if they are involved in the toxicology of A. auriculata. The undesirable effects of EB689 are better understood, the basis for further pharmacological assays aiming antitumor activity are supported. (AU)