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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-range cargo transport on crowded microtubules: The motor jamming mechanism

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Author(s):
Rossi, Lucas W. [1] ; Radtke, Paul K. [2] ; Goldman, Carla [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Fis Geral, Inst Fis, BR-05315970 Sao Paulo - Brazil
[2] Humboldt Univ, Dept Phys, D-12489 Berlin - Germany
Total Affiliations: 2
Document type: Journal article
Source: PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS; v. 401, p. 319-329, MAY 1 2014.
Web of Science Citations: 2
Abstract

The hopping model for cargo transport by molecular motors introduced in Goldman and Sena (2009), Goldman (2010) is extended here in order to incorporate the movement of cargo motor complexes (C-MC). Hopping processes in this context express the possibility for cargo to be exchanged between neighboring motors at a microtubule where the transport takes place. jamming of motors is essential for cargos to execute long-range movement in this way. Results from computer simulations accompanied by a mean-field analysis of the extended model confirm our previous analytical results and suggests that an interplay between cargo hopping and the movement of the C-MC's would control the efficiency of cargo transfer and cargo delivery in these model systems. (C) 2014 Elsevier B.V. All rights reserved. (AU)