F-19 DOSY NMR analysis for spin systems with (n)J(FF) couplings

Author(s)

Dal Poggetto, Guilherme ^[1] ; Favaro, Denize C. ^[1] ; Nilsson, Mathias ^{[2, 3]} ; Morris, Gareth A. ^[2] ; Tormena, Claudio F. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs - England

^[3] Univ Copenhagen, Dept Food Sci, Fac Sci, DK-1958 Frederiksberg C - Denmark

• Document type: Journal article
• Source: Magnetic Resonance in Chemistry; v. 52, n. 4, p. 172-177, APR 2014.
• Web of Science Citations: 14

Abstract

NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as F-19 spectra are typically very sparse. Here, we demonstrate the use of a modified F-19 DOSY experiment (on the basis of the Oneshot sequences) for various fluorinated benzenes. For compounds with significant (n)J(FF) coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This investigation highlights F-19 DOSY as a valuable and robust method for analysis of molecular systems containing fluorine atoms even where there are large fluorine-fluorine couplings. Copyright (c) 2014 John Wiley \& Sons, Ltd. (AU)

• FAPESP's process: 13/03477-2 - DOSY methods for analyses of the complex mixtures
• Grantee: Claudio Francisco Tormena
• Support Opportunities: Regular Research Grants