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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle

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Author(s):
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Utsunomiya, Yuri T. [1] ; Carmo, Adriana S. [1] ; Neves, Haroldo H. R. [2] ; Carvalheiro, Roberto [3, 2] ; Matos, Marcia C. [1] ; Zavarez, Ludmilla B. [1] ; Ito, Pier K. R. K. [4] ; O'Brien, Ana M. Perez ; Soelkner, Johann [5] ; Porto-Neto, Laercio R. [6] ; Schenkel, Flavio S. [7] ; McEwan, John [8] ; Cole, John B. [9] ; da Silva, Marcos V. G. B. [10] ; Van Tassell, Curtis P. ; Sonstegard, Tad S. [11] ; Garcia, Jose Fernando [1, 4]
Total Authors: 17
Affiliation:
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[1] UNESP Univ Estadual Paulista, Fac Ciencias Agr & Vet, Dept Med Vet Prevent & Reprod Anim, Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Dept Zootecnia, Sao Paulo - Brazil
[3] GenSys Consultores Associados, Porto Alegre, RS - Brazil
[4] UNESP Univ Estadual Paulista, Fac Med Vet Aracatuba, Dept Apoio Saude & Prod Anim, Sao Paulo - Brazil
[5] BOKU Univ Nat Resources & Life Sci, Div Livestock Sci, Dept Sustainable Agr Syst, Vienna - Austria
[6] CSIRO Commonwealth Sci & Ind Res Org, Food Futures Flagship, Brisbane, Qld - Australia
[7] Univ Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1 - Canada
[8] AgResearch, Ctr Reprod & Genom, Mosgiel, Otago - New Zealand
[9] ARS, Anim Improvement Programs Lab, USDA, Beltsville, MD - USA
[10] Embrapa Dairy Cattle, Bioinformat & Anim Genom Lab, Juiz De Fora, MG - Brazil
[11] ARS, Bovine Funct Genom Lab, USDA, Beltsville, MD - USA
Total Affiliations: 11
Document type: Journal article
Source: PLoS One; v. 9, n. 2 FEB 18 2014.
Web of Science Citations: 24
Abstract

The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility. (AU)

FAPESP's process: 11/16643-2 - Genome-Wide Association Study for detection of chromosomal regions related to scrotal circumference in Nellore cattle
Grantee:Yuri Tani Utsunomiya
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/52030-2 - Genome wide association study for reproductive traits in zebu bulls (Bos indicus) using high-density SNP chip
Grantee:José Fernando Garcia
Support type: Regular Research Grants