Ytterbium(III)-Catalyzed Addition Reaction of Alkynyltrifluoroborate Salts to alpha-Imino Esters: Efficient Synthesis of beta-Unsaturated alpha-Amino Esters

Stefani, Helio A.; Manarin, Flavia; Khan, Amna N.; Vasconcelos, Stanley N. S.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ytterbium(III)-Catalyzed Addition Reaction of Alkynyltrifluoroborate Salts to alpha-Imino Esters: Efficient Synthesis of beta-Unsaturated alpha-Amino Esters

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Author(s):	Stefani, Helio A. ^[1] ; Manarin, Flavia ^[1] ; Khan, Amna N. ^[1] ; Vasconcelos, Stanley N. S. ^[1] Total Authors: 4
Affiliation:	^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2014, n. 6, p. 1236-1240, FEB 2014.
Web of Science Citations:	7
Abstract
We describe the development of a mild and efficient method for the preparation of -unsaturated -amino esters through the ytterbium triflate catalyzed addition of potassium alkynyltrifluoroborate salts to imino esters. The synthetic viability of this protocol was supported by its high yields, short reaction times, and efficiency with regard to the scope of the substrates. (AU)

FAPESP's process:	12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:	Helio Alexandre Stefani
Support Opportunities:	Research Projects - Thematic Grants

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