| Full text | |
| Author(s): |
da Silva, Fabiano Pinheiro
[1]
;
Cesar Machado, Marcel Cerqueira
[1]
;
Sallet, Paulo Clemente
[2]
;
Zampieri, Fernando Godinho
[1]
;
Goulart, Alessandra Carvalho
[3]
;
Torggler Filho, Francisco
[1]
;
Barbeiro, Hermes Vieira
[1]
;
Velasco, Irineu Tadeu
[1]
;
da Cruz Neto, Luiz Monteiro
[1]
;
de Souza, Heraldo Possolo
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Dept Emergency Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Clin Res Ctr, Univ Hosp, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Inflammation; v. 37, n. 1, p. 142-145, FEB 2014. |
| Web of Science Citations: | 3 |
| Abstract | |
Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammatory signaling, and many others. The effects of neuropeptides in the pathophysiology of sepsis, however, remain poorly investigated. A prospective cohort study to investigate the effects of neuropeptides in sepsis was carried out. Here, we describe that neuropeptides are downregulated during septic shock. We propose that it may be a protective mechanism of the host to avoid further inflammatory injury. (AU) | |
| FAPESP's process: | 09/17731-2 - Markers of infection in critically ill patients |
| Grantee: | Fabiano Pinheiro da Silva |
| Support Opportunities: | Research Grants - Young Investigators Grants |