| Full text | |
| Author(s): Show less - |
Boszczowski, Icaro
[1]
;
do Prado, Gladys Villas Boas
[1]
;
Dalben, Mirian F.
[1]
;
Telles, Roberto C. P.
[2, 3]
;
Freire, Maristela Pinheiro
[1]
;
Guimaraes, Thais
[1]
;
Oliveira, Maura S.
[1]
;
Rosa, Juliana F.
[2, 3]
;
Soares, Robson E.
[2, 3, 4]
;
Llacer, Pedro Enrique Dorlhiac
[5]
;
Dulley, Frederico Luiz
[6]
;
Costa, Silvia F.
;
Levin, Anna S.
[1, 2, 3]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Infect Control Dept, Hosp Clin, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Infect Dis, Sao Paulo - Brazil
[3] Univ Sao Paulo, LIM 54, Sao Paulo - Brazil
[4] Pontificia Univ Catolica Sao Paulo, Sao Paulo - Brazil
[5] Univ Sao Paulo, Hosp Clin, Hematol Unit, Sao Paulo - Brazil
[6] Univ Sao Paulo, Hosp Clin, Bone Marrow Transplant Unit, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Revista do Instituto de Medicina Tropical de São Paulo; v. 56, n. 1, p. 71-76, JAN-FEB 2014. |
| Web of Science Citations: | 5 |
| Abstract | |
Aim: The objective was to describe an outbreak of bloodstream infections by Burkholderia cepacia complex (Bcc) in bone marrow transplant and hematology outpatients. Methods: On February 15, 2008 a Bcc outbreak was suspected. 24 cases were identified. Demographic and clinical data were evaluated. Environment and healthcare workers' (HCW) hands were cultured. Species were determined and typed. Reinforcement of hand hygiene, central venous catheter (CVC) care, infusion therapy, and maintenance of laminar flow cabinet were undertaken. 16 different HCWs had cared for the CVCs. Multi-dose heparin and saline were prepared on counter common to both units. Findings: 14 patients had B. multivorans (one patient had also B. cenopacia), six non-multivorans Bcc and one did not belong to Bcc. Clone A B. multivorans occurred in 12 patients (from Hematology); in 10 their CVC had been used on February 11/12. Environmental and HCW cultures were negative. All patients were treated with meropenem, and ceftazidime lock-therapy. Eight patients (30%) were hospitalized. No deaths occurred. After control measures (multidose vial for single patient; CVC lock with ceftazidime; cleaning of laminar flow cabinet; hand hygiene improvement; use of cabinet to store prepared medication), no new cases occurred. Conclusions: This polyclonal outbreak may be explained by a common source containing multiple species of Bcc, maybe the laminar flow cabinet common to both units. There may have been contamination by B. multivorans (clone A) of multi-dose vials. (AU) | |
| FAPESP's process: | 10/09714-8 - Investigation of a Burkholderia cepacea outbreak in patients with bone marrow transplant or hematologic cancer |
| Grantee: | Roberto Caraver Prado Telles |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |