Albocycline, the main bioactive compound from Propionicimonas sp ENT-18 against Sclerotinia sclerotiorum

Author(s)

Zucchi, Tiago D. ^{[1, 2]} ; Almeida, Luis G. ^[1] ; Moraes, Luiz A. B. ^[3] ; Consoli, Fernando L. ^[1]

Affiliation

^[1] Univ Sao Paulo ESALQ USP, Escola Super Agr Luiz de Queiroz, Dept Entomol & Acarol, Lab Microbiol Ambiental, BR-13418900 Piracicaba, SP - Brazil

^[2] EMBRAPA Meio Ambiente, Lab Microbiol Ambiental, BR-13820000 Jaguariuna, SP - Brazil

^[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto - Brazil

• Document type: Journal article
• Source: INDUSTRIAL CROPS AND PRODUCTS; v. 52, p. 264-268, JAN 2014.
• Web of Science Citations: 5

Abstract

The main aim of this study was to identify the active compound produced by the ant ectosymbiont Propionicimonas sp. ENT-18 against Sclerotinia sclerotiorum. An ethyl acetate whole extract from ENT-18 fermented broth was fractionated on Sephadex and Fluorisil columns prior to Q-TOF mass spectrometry analysis. The active fraction was found to contain the macrolide albocycline, which was deduced by interpreting the magnetic resonance data. Low concentration (1.6 mu g/sclerotium) of the purified albocycline was sufficed to inhibit the sclerotia germination. Albocycline was considered as the main active molecule produced by ENT-18 against S. sclerotiorum. This is the first report of albocycline produced by a non-streptomycete and of its potential as an antimold molecule. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 11/14333-6 - Diversity and polyphasic taxonomy of actinobacteria isolated from reforestation areas
• Grantee: Tiago Domingues Zucchi
• Support Opportunities: Scholarships in Brazil - BIOTA - Young Researchers
• FAPESP's process: 11/50877-0 - Diversity, ecology and biotechnological potential of the symbiotic bacteriofauna associated with insects
• Grantee: Fernando Luis Cônsoli
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants