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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Edinger-Westphal nucleus II: Hypothalamic afferents in the rat

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Author(s):
da Silva, Andre V. [1, 2] ; Torres, Kelly R. [1, 2] ; Haemmerle, Carlos A. [1] ; Cespedes, Isabel C. [1, 3] ; Bittencourt, Jackson C. [1, 4]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anatomy, Lab Chem Neuroanat, BR-05508000 Sao Paulo - Brazil
[2] Sao Paulo State Univ, Inst Biosci, Dept Anat, BR-18618970 Botucatu, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biomed Sci, BR-11060001 Santos - Brazil
[4] Univ Sao Paulo, Ctr Neurosci & Behav, Inst Psychol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Chemical Neuroanatomy; v. 54, p. 5-19, DEC 2013.
Web of Science Citations: 12
Abstract

Numerous functions have been attributed to the Edinger-Westphal nucleus (EW), including those related to feeding behavior, pain control, alcohol consumption and the stress response. The LW is thought to consist of two parts: one controls accommodation, choroidal blood flow and pupillary constriction, primarily comprising cholinergic cells and projecting to the ciliary ganglion; and the other would be involved in the non-ocular functions mentioned above, comprising peptide-producing neurons and projecting to the brainstem, spinal cord and prosencephalic regions. Despite the fact that the EW is well known, its connections have yet to be described in detail. The aim of this work was to produce a map of the hypothalamic sources of afferents to the EW in the rat. We injected the retrograde tracer Fluoro-Gold into the EW, and using biotinylated dextran amine, injected into afferent sources as the anterograde control. We found retrogradely labeled cells in the following regions: subfornical organ, paraventricular hypothalamic nucleus, arcuate nucleus, lateral hypothalamic area, zona incerta, posterior hypothalamic nucleus, medial vestibular nucleus and cerebellar interpositus nucleus. After injecting BDA into the paraventricular hypothalamic nucleus, lateral hypothalamic area and posterior hypothalamic nucleus, we found anterogradely labeled fibers in close apposition to and potential synaptic contact with urocortin 1-immunoreactive cells in the EW. On the basis of our findings, we can suggest that the connections between the EW and the hypothalamic nuclei are involved in controlling stress responses and feeding behavior. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 04/13849-5 - Peptidergic pathways involved in the organization of feeding behavior
Grantee:Jackson Cioni Bittencourt
Support type: Research Projects - Thematic Grants