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Peptidergic pathways involved in the organization of feeding behavior

Grant number: 04/13849-5
Support type:Research Projects - Thematic Grants
Duration: May 01, 2005 - April 30, 2010
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Jackson Cioni Bittencourt
Grantee:Jackson Cioni Bittencourt
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Gilberto Fernando Xavier ; Newton Sabino Canteras
Associated scholarship(s):07/56975-9 - Study of melanin-concentrating hormone (MCH) immunoreactive inputs of nucleus acumbens, in rats Long-Evans , BP.MS

Abstract

Feeding behavior is an essential part of the energy balance control. It allows the maintenance of health and an adequate body weight. In the last years, the description of leptin action as a lipostatic or satiety factor in the hypotha1amus originated a burst of information about its action in food intake control and related disorders (obesity and anorexia). In parallel, an increasing number of peptides and receptors implicated in energy homeostasis have invaded the field. In this regard, melanin-concentrating hormone (MCH) has been related to the tonic control of feeding. MCH neurons are located in the hypothalamus, what made it a natural candidate for neuroendocrine, autonomic and behavioral control of the homeostasis and species subsistence. Accordingly, various findings support MCH action in feeding behavior: 1) MCH mRNA is abundant in fasted animals or obese (ob/ob) mice; 2) MCH administration in the cerebral ventricles or in specific hypothalamic nuclei that express MCH receptor (MCH -IR) induces hyperphagia and increases body weight; 3) MCH knock-out mice shows decreased body weight due to hypophagia and rise in energy expenditure; 4) MCH-IR knock-out mice are lean albeit hyperphagic; 5) administration of MCH-IR specific antagonists decreases body weight gain. Intriguingly however, the brain sites where MCH mar act inducing feeding, and the cell biology of these putative systems are not completely understood. It is important to point out that feeding is a complex behavior that includes homeostatic and hedonistic mechanisms, embracing since hunger sensation until motor activity, exploratory behavior, emotional responses, anxiety, memory and learning processes. Therefore, this study attempts to investigate MCH action in various feeding aspects and the related circuitry. Initially, we plain to analyze MCH participation in spatial orientation in the search for food, using a maze paradigm and different types of food: only nutritional or with hedonic value. In addition, using the same paradigm we propose to investigate the animal performance following lesion, or injection of MCH or anti-MCH in specific brain nuclei previously identified. In these regions, we intend to investigate the neurochemistry, the occurrence of synaptic terminals using electron microscopy, and describe the synaptic characterization. Finally, we aim to look into MCH role in complex systems of search for food that include predatory behavior. (AU)

Scientific publications (23)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BATTAGELLO, DANIELLA S.; DINIZ, GIOVANNE B.; CANDIDO, PAULO L.; DA SILVA, JOELCIMAR M.; DE OLIVEIRA, AMANDA R.; DA SILVA, KELLY R. TORRES; LOTFI, CLAUDIMARA F. P.; DE OLIVEIRA, JOSE A.; SITA, LUCIANE V.; CASATTI, CLAUDIO A.; LOVEJOY, DAVID A.; BITTENCOURT, JACKSON C. Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. FRONTIERS IN NEUROANATOMY, v. 11, JUL 24 2017. Web of Science Citations: 0.
PACHECO FERREIRA, JOZELIA GOMES; BITTENCOURT, JACKSON CIONI; ADAMANTIDIS, ANTOINE. Melanin-concentrating hormone and sleep. CURRENT OPINION IN NEUROBIOLOGY, v. 44, p. 152-158, JUN 2017. Web of Science Citations: 6.
SITA, LUCIANE VALERIA; DINIZ, GIOVANNE BARONI; CANTERAS, NEWTON SABINO; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI. Effect of intrahippocampal administration of anti-melanin-concentrating hormone on spatial food-seeking behavior in rats. Peptides, v. 76, p. 130-138, FEB 2016. Web of Science Citations: 3.
DOS SANTOS JUNIOR, EDMILSON D.; DA SILVA, ANDRE V.; DA SILVA, KELLY R. T.; HAEMMERLE, CARLOS A. S.; BATAGELLO, DANIELLA S.; DA SILVA, JOELCIMAR M.; LIMA, LEANDRO B.; DA SILVA, RENATA J.; DINIZ, GIOVANNE B.; SITA, LUCIANE V.; ELIAS, CAROL F.; BITTENCOURT, JACKSON C. The centrally projecting Edinger-Westphal nucleus-I: Efferents in the rat brain. Journal of Chemical Neuroanatomy, v. 68, p. 22-38, OCT 2015. Web of Science Citations: 12.
HAEMMERLE, C. A. S.; CAMPOS, A. M. P.; BITTENCOURT, J. C. MELANIN-CONCENTRATING HORMONE INPUTS TO THE NUCLEUS ACCUMBENS ORIGINATE FROM DISTINCT HYPOTHALAMIC SOURCES AND ARE APPOSED TO GABAERGIC AND CHOLINERGIC CELLS IN THE LONG-EVANS RAT BRAIN. Neuroscience, v. 289, p. 392-405, MAR 19 2015. Web of Science Citations: 6.
PINATO, LUCIANA; CRUZ-MACHADO, SANSERAY DA SILVEIRA; FRANCO, DAIANE G.; CAMPOS, LEILA M. G.; CECON, ERIKA; FERNANDES, PEDRO A. C. M.; BITTENCOURT, JACKSON C.; MARKUS, REGINA P. Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis. Brain Structure & Function, v. 220, n. 2, p. 827-840, MAR 2015. Web of Science Citations: 28.
CAVALCANTE, JUDNEY CLEY; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats. Brain Research, v. 1582, p. 77-90, SEP 25 2014. Web of Science Citations: 9.
DA SILVA, ANDRE V.; TORRES, KELLY R.; HAEMMERLE, CARLOS A.; CESPEDES, ISABEL C.; BITTENCOURT, JACKSON C. The Edinger-Westphal nucleus II: Hypothalamic afferents in the rat. Journal of Chemical Neuroanatomy, v. 54, p. 5-19, DEC 2013. Web of Science Citations: 12.
LIMA, FERNANDO F. B.; SITA, LUCIANE V.; OLIVEIRA, AMANDA R.; COSTA, HELDER C.; DA SILVA, JOELCIMAR M.; MORTARA, RENATO A.; HAEMMERLE, CARLOS A. S.; XAVIER, GILBERTO F.; CANTERAS, NEWTON S.; BITTENCOURT, JACKSON C. Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat. Journal of Chemical Neuroanatomy, v. 47, p. 1-14, JAN 2013. Web of Science Citations: 11.
MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; BITTENCOURT, JACKSON CIONI; BALDO, MARCUS VINICIUS; ELIAS, CAROL FUZETI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting. Behavioural Brain Research, v. 226, n. 1, p. 32-40, JAN 1 2012. Web of Science Citations: 20.
BITTENCOURT, JACKSON C. Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain. General and Comparative Endocrinology, v. 172, n. 2, p. 185-197, JUN 1 2011. Web of Science Citations: 58.
KOZICZ, TAMAS; BITTENCOURT, JACKSON C.; MAY, PAUL J.; REINER, ANTON; GAMLIN, PAUL D. R.; PALKOVITS, MIKLOS; HORN, ANJA K. E.; TOLEDO, CLAUDIO A. B.; RYABININ, ANDREY E. The Edinger-Westphal Nucleus: A Historical, Structural, and Functional Perspective on a Dichotomous Terminology. JOURNAL OF COMPARATIVE NEUROLOGY, v. 519, n. 8, p. 1413-1434, JUN 1 2011. Web of Science Citations: 92.
AYALA, CAROLINA; RUTH VALDEZ, SUSANA; LUJAN NAVARRA MORERO, MARIA; SOAJE, MARTA; BEATRIZ CARRENO, NORMA; SILVINA SANCHEZ, MONICA; BITTENCOURT, JAKSON CIONI; ALMA JAHN, GRACIELA; ESTER CELIS, MARIA. Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats. Peptides, v. 32, n. 6, p. 1249-1254, JUN 2011. Web of Science Citations: 6.
CESPEDES, ISABEL C.; DE OLIVEIRA, AMANDA R.; DA SILVA, JOELCIMAR M.; DA SILVA, ANDRE V.; SITA, LUCIANE V.; BITTENCOURT, JACKSON C. mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration. Peptides, v. 31, n. 12, p. 2200-2208, DEC 2010. Web of Science Citations: 19.
DONATO, JR., JOSE; CAVALCANTE, JUDNEY CLEY; SILVA, RENATA JULIANA; TEIXEIRA, ALINE STAVIN; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Male and female odors induce Fos expression in chemically defined neuronal population. Physiology & Behavior, v. 99, n. 1, p. 67-77, JAN 2010. Web of Science Citations: 36.
RONDINI, TATIANE ARAUJO; DONATO, JR., JOSE; RODRIGUES, BRUNO DE CRUDIS; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation. Journal of Chemical Neuroanatomy, v. 39, n. 1, p. 51-62, JAN 2010. Web of Science Citations: 24.
GLEZER, ISAIAS; BITTENCOURT, JACKSON C.; RIVEST, SERGE. Neuronal Expression of Cd36, Cd44, and Cd83 Antigen Transcripts Maps to Distinct and Specific Murine Brain Circuits. JOURNAL OF COMPARATIVE NEUROLOGY, v. 517, n. 6, p. 906-924, DEC 20 2009. Web of Science Citations: 27.
MASCARO, MARCELO B.; PROSDOCIMI, FABIO C.; BITTENCOURT, JACKSON C.; ELIAS, CAROL F. Forebrain projections to brainstem nuclei involved in the control of mandibular movements in rats. European Journal of Oral Sciences, v. 117, n. 6, p. 676-684, DEC 2009. Web of Science Citations: 13.
DONATO, JR., JOSE; SILVA, RENATA J.; SITA, LUCIANE V.; LEE, SYANN; LEE, CHARLOTTE; LACCHINI, SILVIA; BITTENCOURT, JACKSON C.; FRANCI, CELSO R.; CANTERAS, NEWTON S.; ELIAS, CAROL F. The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion. JOURNAL OF NEUROSCIENCE, v. 29, n. 16, p. 5240-5250, APR 22 2009. Web of Science Citations: 71.
BITTENCOURT, JACKSON; CELIS, MARIA ESTER. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides, v. 29, n. 8, p. 1441-1450, Aug. 2008. Web of Science Citations: 17.
ELIAS, C. F.; SITA, L. V.; ZAMBON, B. K.; OLIVEIRA, E. R.; VASCONCELOS, L. A. P.; BITTENCOURT, J. C. Melanin-concentrating hormone projections to areas involved in somatomotor responses. Journal of Chemical Neuroanatomy, v. 35, n. 2, p. 188-201, Mar. 2008.
RONDINI‚ T. A.; DE CRUDIS RODRIGUES‚ B.; DE OLIVEIRA‚ A. P.; BITTENCOURT‚ J. C.; ELIAS‚ C. F. Melanin-concentrating hormone is expressed in the laterodorsal tegmental nucleus only in female rats. Brain Research Bulletin, v. 74, n. 1/3, p. 21-28, Sept. 2007.
SITA, L. V.; ELIAS, C. F.; BITTENCOURT, J. C. Connectivity pattern suggests that incerto-hypothalamic area belongs to the medial hypothalamic system. Neuroscience, v. 148, n. 4, p. 949-969, Sept. 2007.

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