Protein synthesis and degradation gene SNPs related to feed intake, feed efficiency, growth, and ultrasound carcass traits in Nellore cattle

Author(s):Show less -

Gomes, R. C. ^[1] ; Silva, S. L. ^[1] ; Carvalho, M. E. ^[1] ; Rezende, F. M. ^[1] ; Pinto, L. F. B. ^[2] ; Santana, M. H. A. ^[1] ; Stella, T. R. ^[1] ; Meirelles, F. V. ^[1] ; Rossi Junior, P. ^[3] ; Leme, P. R. ^[1] ; Ferraz, J. B. S. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Pirassununga, SP - Brazil

^[2] Univ Fed Bahia, Dept Anim Prod, Escola Med Vet, Salvador, BA - Brazil

^[3] Univ Fed Parana, Dept Zootecnia, BR-80060000 Curitiba, Parana - Brazil

• Document type: Journal article
• Source: Genetics and Molecular Research; v. 12, n. 3, p. 2923-2936, 2013.
• Web of Science Citations: 16

Abstract

We looked for possible associations of SNPs in genes related to protein turnover, with growth, feed efficiency and carcass traits in feedlot Nellore cattle. Purebred Nellore bulls and steers (N = 290; 378 +/- 42 kg body weight, 23 months +/- 42 days old) were evaluated for daily feed intake, body weight gain (BWG), gross feed efficiency, feed conversion ratio, partial efficiency of growth, residual feed intake (RFI), ultrasound backfat, rump fat, and ribeye area. Genotypes were obtained for SNPs in the growth hormone receptor (GHR-1 and GHR-2); calpain (CAPN4751); calpastatin (UoGCAST); ubiquitin-conjugating enzyme 2I (UBE2I-1 and UBE2I-2); R3H domain containing 1 (R3HDM1-1, -2, -3, and -4), ring finger protein 19 (RNF19); proteasome 26S subunit, non-ATPase, 13 (PSMD13); ribosomal protein, large, P2 (RPLP2); and isoleucine-tRNA synthetase 2, mitochondrial (IARS2) genes. Allelic substitution, additive and dominant effects were tested and molecular breeding values were computed. CAPN4751, GHR-1 and -2, IARS2, R3HDM1-4, and UoGCAST were found to be normally segregating polymorphisms. Additive and dominance effects were observed on BWG, feed efficiency and carcass traits, although dominant effects predominated. Significant allelic substitution effects were observed for CAPN4751, GHR-1 and -2, and UoGCAST on BWG, gross feed efficiency, RFI, and carcass traits, under single-or multiple-marker analyses. Correlations between molecular breeding values and phenotypes were low, excepted for RFI, based on allelic substitution estimates obtained by stepwise linear regression. We conclude that SNPs in genes related to protein turnover are related to economically important traits in Nellore cattle. (AU)

• FAPESP's process: 08/11363-9 - Polymorphisms in genes related to intracellular protein synthesis and degradation, and their relationships with residual feed intake in Nellore cattle
• Grantee: José Bento Sterman Ferraz
• Support type: Regular Research Grants
• FAPESP's process: 08/10098-0 - Polymorphisms in genes related to intracellular protein synthesis and degradation, and their relationships with residual feed intake in Nellore cattle
• Grantee: Rodrigo da Costa Gomes
• Support type: Scholarships in Brazil - Post-Doctorate