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Genomic study for intake and feed efficiency in Nellore cattle

Grant number: 12/03551-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Agronomical Sciences - Animal Husbandry
Principal Investigator:José Bento Sterman Ferraz
Grantee:Miguel Henrique de Almeida Santana
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Last advances in genetics and molecular biology have made possible the complete sequencing of bovine genome, as well as open wide a new range on this research area. However, studies involving cattle's genomic data with feed intake and feed efficiency are still rare. Several single nucleotide polymorphisms (SNP) have been identified in taurus beef cattle's genes related to weight gain, carcass quality and other production traits. This project aimed to verify SNP in cattle's genome and to associate these with feed intake and feed efficiency of Nellore cattle, the most expressive and important breed under Brazilian cattle. Data will be used for dry matter intake, feed conversion ratio, partial efficiency of growth and residual feed intake of 400 of this breed. These animals will have their genomic DNA extracted and then individually genotyped by commercial chips (BovineSNP50 Beadchip®, Illumina Inc). These genomic data will be used in conjunction with the phenotypic data for the characterization of SNP to calculate gene and genotypic frequencies, additive, allele substitution and dominance effects. In addition, pedigree data will be included to estimate the molecular breeding value of each animal using GBLUP and Bayesian (Bayes A, B, C, CÀ and DÀ) methods.

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTANA, M. H. A.; OLIVEIRA JUNIOR, G. A.; GOMES, R. C.; SILVA, S. L.; LEME, P. R.; STELLA, T. R.; MATTOS, E. C.; ROSSI JUNIOR, P.; BALDI, F. S.; ELER, J. P.; FERRAZ, J. B. S. Genetic parameter estimates for feed efficiency and dry matter intake and their association with growth and carcass traits in Nellore cattle. LIVESTOCK SCIENCE, v. 167, p. 80-85, SEP 2014. Web of Science Citations: 13.
SANTANA, M. H. A.; GOMES, R. C.; OZAWA, G. M.; FUKUMASU, H.; SILVA, S. L.; LEME, P. R.; ROSSI JUNIOR, P.; PIRES, P. R. L.; ALEXANDRE, P. A.; OLIVEIRA, P. S.; MEIRELLES, F. V.; FERRAZ, J. B. S. Single nucleotide polymorphisms in genes linked to ion transport and regulation of appetite and their associations with weight gain, feed efficiency and intake of Nellore cattle. LIVESTOCK SCIENCE, v. 165, p. 33-36, JUL 2014. Web of Science Citations: 0.
SANTANA, M. H. A.; UTSUNOMIYA, Y. T.; NEVES, H. H. R.; GOMES, R. C.; GARCIA, J. F.; FUKUMASU, H.; SILVA, S. L.; LEME, P. R.; COUTINHO, L. L.; ELER, J. P.; FERRAZ, J. B. S. Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus). JOURNAL OF ANIMAL BREEDING AND GENETICS, v. 131, n. 3, p. 210-216, JUN 2014. Web of Science Citations: 10.
SANTANA, MIGUEL H. A.; UTSUNOMIYA, YURI T.; NEVES, HAROLDO H. R.; GOMES, RODRIGO C.; GARCIA, JOSE F.; FUKUMASU, HEIDGE; SILVA, SAULO L.; OLIVEIRA JUNIOR, GERSON A.; ALEXANDRE, PAMELA A.; LEME, PAULO R.; BRASSALOTI, RICARDO A.; COUTINHO, LUIZ L.; LOPES, THIAGO G.; MEIRELLES, FLAVIO V.; ELER, JOANIR P.; FERRAZ, JOSE B. S. Genome-wide association analysis of feed intake and residual feed intake in Nellore cattle. BMC GENETICS, v. 15, FEB 11 2014. Web of Science Citations: 30.

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