Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder

Author(s):Show less -

de Carvalho, Tatiana Dias ^{[1, 2]} ; Wajnsztejn, Rubens ^[3] ; de Abreu, Luiz Carlos ^{[1, 4]} ; Marques Vanderlei, Luiz Carlos ^[5] ; Godoy, Moacir Fernandes ^[6] ; Adami, Fernando ^[1] ; Valenti, Vitor E. ^[7] ; Monteiro, Carlos B. M. ^{[1, 4]} ; Laudio Leone, C. ^[4] ; da Cruz Martins, Karen Cristina ^[1] ; Ferreira, Celso ^[2]

Affiliation

^[1] FMABC, Fac Med ABC, Lab Escrita Cient, Santo Andre - Brazil

^[2] Univ Fed Sao Paulo, UNIFESP, Disciplina Cardiol, Dept Med, Sao Paulo - Brazil

^[3] FMABC, Fac Med ABC, Programa Posgrad Ciencias Saude, Nucl Especializado Aprendizagem, Santo Andre - Brazil

^[4] Univ Sao Paulo, Fac Saude Publ, Dept Saude Maternoinfantil, Sao Paulo - Brazil

^[5] Univ Estadual Paulista, UNESP, Fac Ciencias & Tecnol, Dept Fisioterapia, Sao Paulo - Brazil

^[6] FAMERP, Fac Med Sao Jose de Rio Preto, Nucleo Transdisciplinar Estudos Caos & Complexida, Sao Jose Do Rio Preto - Brazil

^[7] Univ Estadual Paulista, UNESP, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia - Brazil

• Document type: Journal article
• Source: NEUROPSYCHIATRIC DISEASE AND TREATMENT; v. 10, p. 613-618, 2014.
• Web of Science Citations: 14

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is characterized by decreased attention span, impulsiveness, and hyperactivity. Autonomic nervous system imbalance was previously described in this population. We aim to compare the autonomic function of children with ADHD and controls by analyzing heart rate variability (HRV). Methods: Children rested in supine position with spontaneous breathing for 20 minutes. Heart rate was recorded beat by beat. HRV analysis was performed in the time and frequency domains and Poincare plot. Results: Twenty-eight children with ADHD (22 boys, aged 9.964 years) and 28 controls (15 boys, age 9.857 years) participated in this study. It was determined that the mean and standard deviation of indexes which indicate parasympathetic activity is higher in children with ADHD than in children without the disorder: high frequency in normalized units, 46.182 (14.159) versus 40.632 (12.247); root mean square of successive differences, 41.821 (17.834) versus 38.150 (18.357); differences between adjacent normal-to-normal intervals greater than 50 milliseconds, 199.75 (144.00) versus 127.46 (102.21) (P<0.05); percentage of differences between adjacent normal-to-normal intervals greater than 50 milliseconds, 23.957 (17.316) versus 16.211 (13.215); standard deviation of instantaneous beat-to-beat interval, 29.586 (12.622) versus 26.989 (12.983). Conclusion: Comparison of the autonomic function by analyzing HRV suggests an increase in the activity of the parasympathetic autonomic nervous systems in children with ADHD in relation to the control group. (AU)

• FAPESP's process: 13/17628-2 - Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder
• Grantee: Luiz Carlos de Abreu
• Support Opportunities: Regular Research Grants - Publications - Scientific article