Sunscreen protection against ultraviolet-induced oxidative stress: Evaluation of reduced glutathione levels, metalloproteinase secretion, and myeloperoxidase activity

Author(s)

Vilela, F. M. P. ^[1] ; Fonseca, Y. M. ^{[1, 2]} ; Vicentini, F. T. M. C. ^[1] ; Fonseca, M. J. V. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil

^[2] Univ Brasilia, Fac Hlth Sci, BR-70910900 Brasilia, DF - Brazil

• Document type: Journal article
• Source: Pharmazie; v. 68, n. 11, p. 872-876, NOV 2013.
• Web of Science Citations: 3

Abstract

Several studies have demonstrated the skin protection by sunscreens considering the aspects skin penetration, photostability, and protection against erythema and sunburn. However, little is known about the effect of topically applied sunscreen formulations on the antioxidant defense, metalloproteinases, and inflammatory processes of skin in response to UVR exposure. Therefore, this study aimed to investigate the use of a cream gel formulation containing the UV filters benzophenone-3, octyl methoxycinnamate, and octyl salicylate to prevent skin damage from a single dose of UVR (2.87 J/cm(2)). This protective effect was evaluated in vivo by measuring the following biochemical parameters: reduced glutathione levels, secretion of matrix metalloproteinases, and myeloperoxidase activity. The results showed that the sunscreen formulation, despite having sun protection factor (SPF) 15, was not completely effective to protect the skin against GSH depletion, MMP-9 secretion and the inflammatory process induced by UVR. These results demonstrate the importance of analyzing UV-altered biochemical parameters of skin in order to propose new sunscreen formulations that can completely protect skin against UVR-induced damage. (AU)

• FAPESP's process: 09/00924-2 - Evaluation of in vivo safety of ultraviolet filters in sunscreen formulation
• Grantee: Fernanda Maria Pinto Vilela
• Support Opportunities: Scholarships in Brazil - Master