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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Small for gestational age babies are not related to changes in markers of adipose tissue dysfunction during reproductive age

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Author(s):
de Melo, Anderson Sanches [1] ; Bettiol, Heloisa [2] ; Moura da Silva, Antonio Augusto [3] ; Japur Sa Rosa-e-Silva, Ana Carolina [4] ; Cardoso, Viviane Cunha [2] ; dos Reis, Rosana Maria [4] ; Ferriani, Rui Alberto [4] ; Barbieri, Marco Antonio [2] ; Vieira, Carolina Sales [4]
Total Authors: 9
Affiliation:
[1] Univ Hosp, FMRP USP, Fac Med Ribeirao Preto, Dept Gynecol & Obstet, Ribeirao Preto, SP - Brazil
[2] Univ Hosp, FMRP USP, Dept Pediat, Ribeirao Preto, SP - Brazil
[3] Univ Fed Maranhao, Dept Publ Hlth, Sao Luis, MA - Brazil
[4] Univ Hosp, FMRP USP, Dept Gynecol & Obstet, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: EARLY HUMAN DEVELOPMENT; v. 90, n. 5, p. 231-235, MAY 2014.
Web of Science Citations: 6
Abstract

Background: Small for gestational age (SGA) birth has been associated with adipocyte dysfunction during later phases of life. Because SGA women are at a higher risk of developing polycystic ovary syndrome (PCOS), adipocyte dysfunction detected in patients with PCOS may be associated with SGA birth. Aims: To determine whether SGA birth is related to altered serum markers of adipose tissue dysfunction during the third decade of life in Brazilian women. A secondary objective was to relate the presence of PCOS with serum markers of adipose tissue dysfunction. Study design: Prospective cohort observational study. Subjects: A total of 384 women born at 37 to 42 weeks of gestation from June 1, 1978 to May 31, 1979 in Ribeirao Preto, State of Sao Paulo, Brazil. After exclusion, 165 women participated in the study. Of these women, 43 were in the SGA group and 122 were in the adequate for gestational age group based on birth weight determined from cohort files. Outcome measures: Body mass index (BMI), arterial systolic and diastolic pressures, abdominal circumference and serum concentrations of total testosterone, fasting glucose and insulin, lipid profile, adiponectin, leptin and necrosis factor alpha tumor (TNF alpha.). Results: BMI was an independent predictor of lower adiponectin (adjusted coefficient = -0.02, p = 0.01) and higher leptin (adjusted coefficient = 0.06, p = 0.01) concentrations. The serum insulin concentration was associated with higher leptin (adjusted coefficient = 0.03, p = 0.02) and TNF-alpha (adjusted coefficient = 0.01, p = 0.03) concentrations. Having PCOS or being born SGA did not predict any markers of adipocyte dysfunction. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 00/09508-7 - From perinatal health to health of the young adult: study of cohort born in 1978/79 in the hospitals of Ribeirão Preto, SP
Grantee:Marco Antonio Barbieri
Support Opportunities: Research Projects - Thematic Grants