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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The accelerated preparation of 1,4-dihydropyridines using microflow reactors

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Author(s):
Baraldi, Patricia Tambarussi [1, 2] ; Noel, Timothy [1, 3] ; Wang, Qi [1] ; Hessel, Volker [1]
Total Authors: 4
Affiliation:
[1] Eindhoven Univ Technol, Dept Chem Engn & Chem Micro Flow Chem & Proc Tech, NL-5612 AZ Eindhoven - Netherlands
[2] Inst Vita Nova, Hortolandia 13 - Brazil
[3] Univ Ghent, Dept Organ Chem, B-9000 Ghent - Belgium
Total Affiliations: 3
Document type: Journal article
Source: Tetrahedron Letters; v. 55, n. 13, p. 2090-2092, MAR 26 2014.
Web of Science Citations: 10
Abstract

The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6-11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45-88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/20268-2 - Integrated consecutive high-T, high-p Novel Process Windows for flow chemistry synthesis of Dihydropyrines (DHP)
Grantee:Patrícia Tambarussi Baraldi
Support Opportunities: Scholarships abroad - Research