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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conductometric determination of propranolol hydrochloride in pharmaceuticals

Full text
Author(s):
Elen Romão Sartori [1] ; Nathália Vieira Barbosa [2] ; Ronaldo Censi Faria [3] ; Orlando Fatibello-Filho [4]
Total Authors: 4
Affiliation:
[1] Universidade Federal de São Carlos. Departamento de Química. Centro de Ciências Exatas e de Tecnologia - Brasil
[2] Universidade Federal de São Carlos. Departamento de Química. Centro de Ciências Exatas e de Tecnologia - Brasil
[3] Universidade Federal de São Carlos. Departamento de Química. Centro de Ciências Exatas e de Tecnologia - Brasil
[4] Universidade Federal de São Carlos. Departamento de Química. Centro de Ciências Exatas e de Tecnologia - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Eclética Química; v. 36, n. 1, p. 110-122, 2011-00-00.
Abstract

In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method. (AU)

FAPESP's process: 09/04048-2 - Development of nanocomposites electrodes composed of polyaniline and carbon nanotubes and evaluation of electroanalytical response to catecholamines and flavonoids.
Grantee:Nathália Vieira Barbosa
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/14454-8 - Modified carbon electrodes with carbon nanotubes and/or metallic nanoparticles in chitosan film for determination of sulphur compounds in petroleum derivatives and food
Grantee:Elen Julciléia Romão Sartori
Support Opportunities: Scholarships in Brazil - Post-Doctoral