L-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

Author(s)

Zampieri, Thais T. ^[1] ; Torres-Leal, Francisco L. ^{[1, 2]} ; Campana, Amanda B. ^[1] ; Lima, Fabio B. ^[1] ; Donato, Jr., Jose ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil

^[2] Univ Fed Piaui, Dept Biophys & Physiol, BR-64049550 Teresina - Brazil

• Document type: Journal article
• Source: NUTRIENTS; v. 6, n. 4, p. 1364-1373, APR 2014.
• Web of Science Citations: 4

Abstract

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms. (AU)

• FAPESP's process: 12/15517-6 - Involvment of molecular factors in metabolic changes during pregnancy: role of SOCS3
• Grantee: Thais Tessari Zampieri
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/18086-0 - Molecular basis of leptin resistance
• Grantee: Jose Donato Junior
• Support Opportunities: Research Grants - Young Investigators Grants