The 60-and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Author(s)

Nahas, Eliana A. P. ^[1] ; Nahas-Neto, Jorge ^[1] ; Orsatti, Claudio L. ^[1] ; Tardivo, Ana Paula ^[1] ; Uemura, Gilberto ^[1] ; Peracoli, Maria Terezinha S. ^[2] ; Witkin, Steven S. ^[3]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618970 Botucatu Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Microbiol & Immunol, Inst Biosci, BR-18618970 Botucatu Sao Paulo - Brazil

^[3] Weill Cornell Med Coll, Div Immunol & Infect Dis, Dept Obstet & Gynecol, New York, NY - USA

• Document type: Journal article
• Source: CELL STRESS & CHAPERONES; v. 19, n. 4, p. 559-568, JUL 2014.
• Web of Science Citations: 3

Abstract

We investigated the association between circulating levels of 60 and 70 kDa heat-shock proteins (HSP60 and 70) and cardiovascular risk factors in postmenopausal women with or without metabolic syndrome (MetS). This cross-sectional study included 311 Brazilian women (age a parts per thousand yen45 years with amenorrhea a parts per thousand yen12 months). Women showing three or more of the following diagnostic criteria were diagnosed with MetS: waist circumference (WC) a parts per thousand yen88 cm, blood pressure a parts per thousand yen130/85 mmHg, triglycerides a parts per thousand yen150 mg/dl, high-density lipoprotein (HDL) < 50 mg/dl, and glucose a parts per thousand yen100 mg/dl. Clinical, anthropometric, and biochemical parameters were collected. HSP60, HSP70, antibodies to HSP60 and HSP70, and C-reactive protein (CRP) levels were measured in serum. Student's t test, Kruskal-Wallis test, chi-square test, and Pearson correlation were used for statistical analysis. Of the 311 women, 30.9 % (96/311) were diagnosed with MetS. These women were, on average, obese with abdominal fat deposition and had lower HDL values as well as higher triglycerides and glucose levels. Homeostasis model assessment-insulin resistant (HOMA-IR) test values in these women were compatible with insulin resistance (P < 0.05). CRP and HSP60 concentrations were higher in women with MetS than in women without MetS (P < 0.05). HSP60, anti-HSP70, and CRP concentrations increased with the number of features indicative of MetS (P < 0.05). There was a significant positive correlation between anti-HSP70 and WC, blood pressure and HOMA-IR, and between CRP and WC, blood pressure, glucose, HOMA-IR, and triglycerides (P < 0.05). In postmenopausal women, serum HSP60 and anti-HSP70 concentrations increased with accumulating features of the metabolic syndrome. These results suggest a greater immune activation that is associated with cardiovascular risk in postmenopausal women with metabolic syndrome. (AU)

• FAPESP's process: 09/14884-2 - Evaluation of early biomarkers of cardiovascular disease - clinic, inflammatory and ultrasonographic - in postmenopausal women
• Grantee: Eliana Aguiar Petri Nahás
• Support Opportunities: Regular Research Grants