| Full text | |
| Author(s): Show less - |
Yetisen, Ali K.
[1]
;
Montelongo, Yunuen
[2]
;
Vasconcellos, Fernando da Cruz
[1]
;
Martinez-Hurtado, J. L.
[1]
;
Neupane, Sankalpa
[3]
;
Butt, Haider
[4]
;
Qasim, Malik M.
[2]
;
Blyth, Jeffrey
[1]
;
Burling, Keith
[5]
;
Carmody, J. Bryan
[6]
;
Evans, Mark
[3]
;
Wilkinson, Timothy D.
[2]
;
Kubota, Lauro T.
[7]
;
Monteiro, Michael J.
[8]
;
Lowe, Christopher R.
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT - England
[2] Univ Cambridge, Elect Engn Div, Dept Engn, Cambridge CB3 0FA - England
[3] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ - England
[4] Univ Birmingham, Sch Mech Engn, Birmingham B15 2TT, W Midlands - England
[5] Cambridge Univ Hosp NHS Fdn Trust, Core Biochem Assay Lab, Cambridge CB2 0QQ - England
[6] Eastern Virginia Med Sch, Div Nephrol, Dept Pediat, Norfolk, VA 23507 - USA
[7] Univ Estadual Campinas, Natl Inst Sci & Technol Bioanalyt, Inst Chem, BR-13084971 Campinas, SP - Brazil
[8] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072 - Australia
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Nano Letters; v. 14, n. 6, p. 3587-3593, JUN 2014. |
| Web of Science Citations: | 52 |
| Abstract | |
Developing noninvasive and accurate diagnostics that are easily manufactured, robust, and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment. We have developed a clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy. The use of a single 6 ns laser (lambda = 532 nm, 200 mJ) pulse rapidly produced off-axis Bragg diffraction gratings consisting of ordered silver nanoparticles embedded within a phenylboronic acid-functionalized hydrogel. This sensor exhibited reversible large wavelength shifts and diffracted the spectrum of narrow-band light over the wavelength range lambda(peak) approximate to 510-1100 nm. The experimental sensitivity of the sensor permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices. The sensor response was achieved within 5 min, reset to baseline in similar to 10 s. It is anticipated that this sensing platform will have implications for the development of reusable, equipment-free colorimetric point-of-care diagnostic devices for diabetes screening. (AU) | |
| FAPESP's process: | 11/06906-6 - FUNCTIONALIZED MICROFLUIDIC SENSORS WITH BIOPOLYMER NANOSTRUCTURED THIN FILMS THROUGH THE LAYER-BY-LAYER TECHNIQUE |
| Grantee: | Fernando da Cruz Vasconcellos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |