From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

Author(s)

Neuzil, P. ^{[1, 2, 3]} ; Campos, C. D. M. ^{[4, 1]} ; Wong, C. C. ^[2] ; Soon, J. B. W. ^[2] ; Reboud, J. ^[2] ; Manz, A. ^[1]

Affiliation

^[1] KIST Europe Forsch Gesell mbH, DE-66123 Saarbrucken - Germany

^[2] Inst Microelect, Singapore 117685 - Singapore

^[3] Brno Univ Technol, Cent European Inst Technol, CZ-61600 Brno - Czech Republic

^[4] Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: LAB ON A CHIP; v. 14, n. 13, p. 2168-2176, 2014.
• Web of Science Citations: 27

Abstract

We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing system. We demonstrate different configurations to perform most detection schemes currently in use in LOC systems, including some of the most advanced such as nanowire-based biosensing, surface plasmon resonance sensing, electrochemical detection and realtime PCR. The complete system is controlled by a single chip and the collected information is stored in situ, with the option of transferring the data to an external display by using a USB interface. In addition to providing a framework for truly portable real-life developments of LOC systems, we envisage that this system will have a significant impact on education, especially since it can easily demonstrate the benefits of integrated microanalytical systems. (AU)

• FAPESP's process: 13/06625-2 - Development of enzymatic microdevices for glutamate analysis in complex matrixes
• Grantee: Camila Dalben Madeira Campos
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate