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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: correlation of prognostic factors and clinical outcome

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Author(s):
Debora A.P.C. Zuccari [1] ; Marcilia V. Pavam [2] ; Carolina B. Terzian [3] ; Rodrigo S. Pereira [4] ; Camila M. Ruiz [5] ; Joanna Coelho Andrade
Total Authors: 6
Affiliation:
[1] Faculdade de Medicina de São José do Rio Preto. Centro Regional de Bioterismo - Brasil
[2] Faculdade de Medicina de São José do Rio Preto
[3] Unesp-São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas
[4] Centro Universitário de Rio Preto
[5] Laboratório de Patologia e Biologia Molecular Veterinária - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 28, n. 4, p. 207-215, 2008-04-00.
Abstract

E-cadherin is a cell-cell adhesion molecule and low e-cadherin expression is related to invasiveness and may indicate a bad prognosis in mammary neoplasms. The expression of cell proliferation markers PCNA and especially Ki-67, has also proved to have a strong prognostic value in this tumor class. The expression of these markers was related to the clinical-pathological characteristics of 73 surgically removed mammary tumors in female dogs by immunohistochemistry. There was no statistical correlation between these markers and death by neoplasm, survival time and disease-free interval. However, the loss of e-cadherin expression and marked Ki-67 expression (p=0.016) were considered statistically significant for the diagnosis (p=0.032). When evaluated as independent factors, there was evidence of the relationship between the loss of e-cadherin expression and high PCNA expression with changes in the body status (divided into obese, normal and cachectic) of female dogs (p=0.030); there was also evidence of the relationship between pseudopregnancy and e-cadherin alone (p=0.021) and for ulceration and PCNA alone (p=0.035). The significant correlation between the markers expression and these well known prognostic factors used individually or in combination suggests their prognostic value in canine mammary tumors. (AU)