Serum concentration of intact parathormone in dogs with chronic renal failure

Author(s)

P. Lazaretti ; M.M. Kogika ^[2] ; M.K. Hagiwara ^[3] ; M.D. Lustoza ; R.M.S. Mirandola ^[5]

• Document type: Journal article
• Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 58, n. 4, p. 489-494, 2006-08-00.

Abstract

The occurrence of renal secondary hyperparathyroidism was studied and serum intact parathormone (PTHi-c), total calcium and phosphorus were measured in thirty dogs with chronic renal failure (CRF) and in forty healthy dogs. The imunnofluorometric method was used for the PTHi-c assay, using anti-aminoterminal antibodies (obtained from chicken yolk) and anti-carboxiterminal monoclonal antibodies (H5P10), marked with Europium. Mean value ± SD of serum concentration of PTHi-c was 717.23±469.13pg/ml in CRF group and 36.76±34.40pg/ml in control group (P=0.0001); for total calcium it was 11.46±2.03mg/dl in CRF group and 10.11±0.91mg/dl in control group (P=0.003); and for phosphorus it was 12.01±8.06mg/dl in CRF group and 4.33±0.74mg/dl in control group (P=0.0001). The highest values were observed in CRF dogs. A positive correlation between PHTi-c and phosphorus was observed (r=0.56; p=0.0006), and no correlation was detected between PTHi-c and total calcium. In dogs with CRF, hypercalcemia in presence of high level of serum PTHi-c showed a possible indication of tertiary hyperparathyroidism in 11 animals. In conclusion, hyperphosphatemia could indirectly demonstrate the occurrence of secondary hyperparathyroidism in CRF dogs. (AU)