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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Muscle sympathetic nerve activity and hemodynamic alterations in middle-aged obese women

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Author(s):
M.M. Ribeiro [1] ; I.C. Trombetta [2] ; L.T. Batalha [3] ; M.U.P.B. Rondon [4] ; C.L.M. Forjaz [5] ; A.C.P. Barretto [6] ; S.M.F. Villares [7] ; C.E. Negrão
Total Authors: 8
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração
[2] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração
[3] Universidade de São Paulo. Faculdade de Medicina. Departamento de Endocrinologia
[4] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração
[5] Universidade de São Paulo. Escola de Educação Física e Esportes - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração
[7] Universidade de São Paulo. Faculdade de Medicina. Departamento de Endocrinologia
Total Affiliations: 8
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 34, n. 4, p. 475-478, 2001-04-00.
Abstract

To study the relationship between the sympathetic nerve activity and hemodynamic alterations in obesity, we simultaneously measured muscle sympathetic nerve activity (MSNA), blood pressure, and forearm blood flow (FBF) in obese and lean individuals. Fifteen normotensive obese women (BMI = 32.5 ± 0.5 kg/m²) and 11 age-matched normotensive lean women (BMI = 22.7 ± 1.0 kg/m²) were studied. MSNA was evaluated directly from the peroneal nerve by microneurography, FBF was measured by venous occlusion plethysmography, and blood pressure was measured noninvasively by an autonomic blood pressure cuff. MSNA was significantly increased in obese women when compared with lean control women. Forearm vascular resistance and blood pressure were significantly higher in obese women than in lean women. FBF was significantly lower in obese women. BMI was directly and significantly correlated with MSNA, blood pressure, and forearm vascular resistance levels, but inversely and significantly correlated with FBF levels. Obesity increases sympathetic nerve activity and muscle vascular resistance, and reduces muscle blood flow. These alterations, taken together, may explain the higher blood pressure levels in obese women when compared with lean age-matched women. (AU)

FAPESP's process: 98/15983-8 - Genetic and ambiental aspects of obesity
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants