| Full text | |
| Author(s): |
Ana Cristina Breithaupt-Faloppa
[1]
;
Pedro Fernandes Lara
;
Marinilce Fagundes dos Santos
[3]
;
Ricardo Martins Oliveira-Filho
[4]
;
Oswaldo Crivello Junior
[5]
Total Authors: 5
|
| Affiliation: | [1] University of Sao Paulo School of Dentistry. Department of Maxillofacial Surgery, Prosthesis and Traumatology - Brasil
[3] University of Sao Paulo. Institute of Biomedical Sciences. Department of Histology and Embryology - Brasil
[4] University of Sao Paulo. Institute of Biomedical Sciences. Department of Histology and Embryology - Brasil
[5] University of Sao Paulo School of Dentistry. Department of Maxillofacial Surgery, Prosthesis and Traumatology - Brasil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Journal of Applied Oral Science; v. 12, n. 1, p. 78-83, 2004-03-00. |
| Abstract | |
BACKGROUND: Scientific approach of the bone reaction after surgical procedures provides valuable information on methods and techniques. The purpose of this study was to follow this process using a radioisotope marker of bone remodelling. MATERIAL AND METHODS: Two bone cavities were created (one for every tibia) in adult Wistar male rats using a 0.5 mm spherical burr; left tibial cavities were filled with bovine freeze-dried bone; the right ones were left unfilled for control. Scintigrams were done with sodium methylene diphosphonate (MDP) labelled with radioactive pertechnetate (99mTcO4-) to evaluate the inflammatory response and the local osteoblastic activity. The evolution of bone repair was additionally evaluated by light microscopy. RESULTS: Our results have shown that the highest bone activity was recorded between the 7th and the 14th day after surgery. The morphological analysis confirmed the results obtained with radioisotope analysis and did not reveal significant differences regarding the evolution of bone repair between the filled and the unfilled defects. CONCLUSION: We confirmed that 99mTc -MDP is a valuable tool to study bone repair, as it was able to show subtle alterations of bone activity even in lesions as small as those created herein (0.5 mm wide, 0.5 mm deep). (AU) | |