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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Focal adhesion kinase signaling in cardiac hypertrophy and failure

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K.G. Franchini ; C.F.M.Z. Clemente ; T.M. Marin
Total Authors: 3
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 42, n. 1, p. 44-52, Jan. 2009.

Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure. (AU)