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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Kinetics of colostral antibodies against epsilon toxin produced by Clostridium perfringens type D in lambs

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Author(s):
Heni F. Costa [1] ; Selene D. Babboni [2] ; Carlos F.C. Rodrigues [3] ; Carlos R. Padovani [4] ; Iveraldo S. Dutra [5] ; José R. Modolo [6]
Total Authors: 6
Affiliation:
[1] Universidade Estadual Paulista. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Higiene Veterinária e Saúde Pública - Brasil
[2] Universidade Estadual Paulista. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Higiene Veterinária e Saúde Pública - Brasil
[3] Unesp. Instituto de Biociências. Departamento de Bioestatística
[4] Agência Paulista de Tecnologia dos Agronegócios. Unidade de Pesquisa e Desenvolvimento - Brasil
[5] Unesp. Faculdade de Medicina Veterinária. Departamento de Apoio, Produção e Saúde Animal - Brasil
[6] Universidade Estadual Paulista. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Higiene Veterinária e Saúde Pública - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 32, n. 1, p. 17-21, 2012-01-00.
Abstract

Enterotoxemia, a disease that affect small ruminants, is caused mainly by the epsilon toxin from Clostridium perfringens type D. This study evaluated the kinetics of epsilon antitoxin colostral antibodies in lambs born to ewes submitted to two different types of health management. A group of pregnant ewes (n=6) was vaccinated with a single dose of commercial vaccine against polyvalent clostridial toxoid containing epsilon in its formulation some 30 days before the expected date of birth. Another group of ewes (n=6) of the same gestational age were not vaccinated. Immediately after birth, before intake of colostrum, blood samples were collected from their lambs as well as 30 and 60 days of age for serum evaluation by ELISA. The results allow to conclude that vaccination of pregnant ewes 30 days before parturition allowed the transfer of colostral antibodies specific enough to guarantee the immunity considered protective (0,5UI/ml) of the newborn lamb against enterotoxemia until its entry into the feedlot, with 60 days of age. (AU)

FAPESP's process: 08/10957-2 - Evaluation of serological of the immunoprophylaxis enterotoxaemia caused by epsilon toxin of Clostridium perfringens type D in sheep
Grantee:José Rafael Módolo
Support Opportunities: Regular Research Grants