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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Local anesthetics: interaction with biological membranes and with the voltage-gated sodium channel

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Author(s):
Daniele Ribeiro de Araujo [1] ; Eneida de Paula [2] ; Leonardo Fernandes Fraceto [3]
Total Authors: 3
Affiliation:
[1] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Bioquímica - Brasil
[2] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Bioquímica - Brasil
[3] Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Engenharia Ambiental - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Química Nova; v. 31, n. 7, p. 1775-1783, 2008-00-00.
Abstract

Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase. (AU)

FAPESP's process: 06/00121-9 - New formulations for the controlled release of local anesthetics in dentistry: from development to clinical tests
Grantee:Eneida de Paula
Support Opportunities: Research Projects - Thematic Grants