| Full text | |
| Author(s): |
Jaine H. H. Luiz de Oliveira
[1]
;
Ana Claudia Granato
[2]
;
Daniela B. Hirata
[3]
;
Carlos O. Hokka
[4]
;
Marlei Barboza
[5]
;
Milan Trsic
[6]
Total Authors: 6
|
| Affiliation: | [1] Universidade Federal de São Carlos. Departamento de Engenharia Química - Brasil
[2] Universidade Federal de São Carlos. Departamento de Engenharia Química - Brasil
[3] Universidade Federal de São Carlos. Departamento de Engenharia Química - Brasil
[4] Universidade Federal de São Carlos. Departamento de Engenharia Química - Brasil
[5] Universidade Federal de São Carlos. Departamento de Engenharia Química - Brasil
[6] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Química Nova; v. 32, n. 8, p. 2142-2150, 2009-00-00. |
| Abstract | |
The present article reviews different aspects of the chemistry of two widely used β-lactam antibiotics Clavulanic Acid and Cephamycin C. The article discusses important details of the biosynthesis of these compounds, their action mechanism and, principally, the methods employed in their isolation and purification, in accordance with the available literature. Despite the large quantity of available articles and patents concerning β-lactam antibiotics, those which describe the isolation and purification of Clavulanic Acid and Cephamycin C are rare. Overall, the intention of this article is to discuss the up-to-date scientific research related to the compounds under review. (AU) | |
| FAPESP's process: | 05/55079-4 - Production and purification of clavulanic acid, cephamycin C and other bioactive metabolites of Streptomyces |
| Grantee: | Carlos Osamu Hokka |
| Support Opportunities: | Research Projects - Thematic Grants |