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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Restraint-induced hypoactivity in an elevated plus-maze

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Author(s):
C.M. Padovan [1] ; F.S. Guimarães [2]
Total Authors: 2
Affiliation:
[1] Universidade de São Paulo - Brasil
[2] Universidade de São Paulo - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 33, n. 1, p. 79-83, 2000-01-00.
Abstract

Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes. We also wanted to verify if behavioral tolerance of repeated daily restraint would be detectable in this model. Male Wistar rats were restrained for 2 h and tested in the EPM 1, 2, 24 or 48 h later. Another group of animals was immobilized daily for 2 h for 7 days, being tested in the EPM 24 h after the last restraint period. Restraint induced a significant decrease in the percent of entries and time spent in the open arms, as well as a decrease in the number of enclosed arm entries. The significant effect in the number of entries and the percentage of time spent in the open arms disappeared when the data were submitted to analysis of covariance using the number of enclosed arm entries as a covariate. This suggests that the restraint-induced hypoactivity influences the measures of open arm exploration. The modifications of restraint-induced hypoactivity are evident 24 or 48 h, but not 1 or 2 h, after stress. In addition, rats stressed daily for seven days became tolerant to this effect. (AU)

FAPESP's process: 98/10639-7 - Neurobiology of Behavioral responses to aversive events
Grantee:Francisco Silveira Guimaraes
Support Opportunities: Research Projects - Thematic Grants