| Full text | |
| Author(s): |
Albas, Avelino
[1]
;
de Almeida Campos, Angelica Cristine
[2]
;
Araujo, Danielle Bastos
[2]
;
Rodrigues, Camila Seabra
[2]
;
Sodre, Miriam Martos
[3]
;
Durigon, Edison Luiz
[2]
;
Favoretto, Silvana Regina
[2, 4]
Total Authors: 7
|
| Affiliation: | [1] Agencia Paulista Tecnol Agronegocios Presidente P, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Nucleo Pesquisas Raiva, Lab Virol Clin & Mol, BR-05508 Sao Paulo - Brazil
[3] Prefeitura Municipal Sao Paulo, Lab Zoonoses & Doencas Transmitidas Vetores, Ctr Controle Zoonoses, Sao Paulo - Brazil
[4] Inst Pasteur Sao Paulo, Diagnost Lab, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Revista da Sociedade Brasileira de Medicina Tropical; v. 44, n. 6, p. 678-683, NOV-DEC 2011. |
| Web of Science Citations: | 10 |
| Abstract | |
INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haematophagous bat Desmodus rotundus is the main source of infection, where several different species of non-haematophagous bats can be infected and can transmit the virus. METHODS: The aim of this work was to study the epidemiological pattern of rabies using antigenic characterization with monoclonal antibodies and genetic characterization by reverse-transcriptase polymerase chain reaction followed by sequencing and phylogenetic analysis of non-haematophagous bats' and herbivorous animals' central nervous system samples from the western region of the State of São Paulo, Brazil. RESULTS: From 27 samples, 3 antigenic variants were identified: AgV-3, AgV-4, and AgV-6; and from 29 samples, 5 different clusters were identified, all belonging to the rabies virus species. CONCLUSIONS: Although only non-haematophagous bats were evaluated in the studied region, the majority of samples were from antigenic and genetic variants related to haematophagous bats Desmodus rotundus. Samples from the same antigenic variant were segregated in more than one genetic cluster. This study demonstrated the diversity of rabies virus genetic lineages presented and circulating in non-haematophagous bats in the studied region. (AU) | |
| FAPESP's process: | 07/01843-0 - Genetic study of rabies virus variant maintained by hematophagous bats Desmodus rotundus by viral genome complete sequencing |
| Grantee: | Silvana Regina Favoretto |
| Support Opportunities: | Regular Research Grants |