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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of beta(S) haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil

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Kitayama Cabral, Cynthia Hatsue [1] ; Soares Serafim, Edvis Santos [2] ; Dantas Bezerra de Medeiros, Waleska Rayane [1] ; Araujo de Medeiros Fernandes, Thales Allyrio [3] ; Kimura, Elza Miyuki [4] ; Costa, Fernando Ferreira [5] ; Sonati, Maria de Fatima [4] ; Moretti Rebecchi, Ivanise Marina [1] ; Dantas de Medeiros, Tereza Maria [1]
Total Authors: 9
[1] Univ Fed Rio Grande do Norte, Dept Anal Clin & Toxicol, BR-59010180 Natal, RN - Brazil
[2] Hemoctr Dalton Barbosa Cunha, Natal, RN - Brazil
[3] Univ Estado Rio Grande do Norte, Dept Ciencias Biomed, Mossoro, RN - Brazil
[4] Univ Estadual Campinas, Dept Patol Clin, Fac Ciencias Med, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Hemoctr, Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: GENETICS AND MOLECULAR BIOLOGY; v. 34, n. 3, p. 421-424, 2011.
Web of Science Citations: 4

beta(S) haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. (AU)

FAPESP's process: 08/57441-0 - Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias
Grantee:Fernando Ferreira Costa
Support type: Research Projects - Thematic Grants