Bantu haplotype modulation of the response to the hydroxyurea usage in sickle cell...
| Full text | |
| Author(s): |
Kitayama Cabral, Cynthia Hatsue
[1]
;
Soares Serafim, Edvis Santos
[2]
;
Dantas Bezerra de Medeiros, Waleska Rayane
[1]
;
Araujo de Medeiros Fernandes, Thales Allyrio
[3]
;
Kimura, Elza Miyuki
[4]
;
Costa, Fernando Ferreira
[5]
;
Sonati, Maria de Fatima
[4]
;
Moretti Rebecchi, Ivanise Marina
[1]
;
Dantas de Medeiros, Tereza Maria
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Fed Rio Grande do Norte, Dept Anal Clin & Toxicol, BR-59010180 Natal, RN - Brazil
[2] Hemoctr Dalton Barbosa Cunha, Natal, RN - Brazil
[3] Univ Estado Rio Grande do Norte, Dept Ciencias Biomed, Mossoro, RN - Brazil
[4] Univ Estadual Campinas, Dept Patol Clin, Fac Ciencias Med, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Hemoctr, Campinas, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 34, n. 3, p. 421-424, 2011. |
| Web of Science Citations: | 4 |
| Abstract | |
beta(S) haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. (AU) | |
| FAPESP's process: | 08/57441-0 - Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias |
| Grantee: | Fernando Ferreira Costa |
| Support type: | Research Projects - Thematic Grants |