Lithium increases nitric oxide levels in subjects with bipolar disorder during depressive episodes

Author(s)

de Sousa, Rafael T. ^[1] ; Zanetti, Marcus V. ^{[2, 1, 3]} ; Busatto, Geraldo F. ^{[2, 3]} ; Mouro, Margaret G. ^[4] ; Zarate, Jr., Carlos A. ^[5] ; Gattaz, Wagner F. ^{[2, 1]} ; Higa, Elisa M. ^[5] ; Machado-Vieira, Rodrigo ^{[2, 5, 1]}

Affiliation

^[1] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci, LIM 27, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, LIM 21, BR-05508 Sao Paulo - Brazil

^[4] UNIFESP Escola Paulista Med, Div Nephrol, Dept Med, Sao Paulo - Brazil

^[5] NIMH, ETPB, NIH, Bethesda, MD 20892 - USA

• Document type: Journal article
• Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 55, p. 96-100, AUG 2014.
• Web of Science Citations: 10

Abstract

Background: Altered nitric oxide (NO) signaling has been associated with the pathophysiology of Bipolar Disorder (BD), directly affecting neurotransmitter release and synaptic plasticity cascades. Lithium has shown to regulate NO levels in preclinical models. However, no study has addressed peripheral NO levels in unmedicated BD. Also, lithium's effects on NO levels have not been studied in humans. Methods: Plasma NO was evaluated in subjects with BD I and II during a depressive episode (n = 26). Subjects had a score of >= 18 in the 21-item Hamilton Depression Rating Scale and were followed-up during a 6-week trial with lithium. Plasma NO levels were also compared to matched healthy controls (n = 28). NO was determined by chemiluminescence method. Results: Lithium treatment significantly increased plasma NO levels after 6 weeks of treatment in comparison to baseline levels in bipolar depression (p = 0.016). Baseline NO levels during depressive episodes showed no difference when matching up to healthy controls (p = 0.66). Conclusion: The present findings suggest that lithium upregulates NO signaling in unmedicated BD with short illness duration. Further studies with larger samples are needed to confirm the effects of lithium on NO pathway and its association with synaptic plasticity and therapeutics of BD. Published by Elsevier Ltd. (AU)

• FAPESP's process: 09/14891-9 - Longitudinal study on the neuroprotective and neurotrophic effects of lithium in bipolar disorder: identification of cellular and molecular targets clinically relevant
• Grantee: Rodrigo Machado-Vieira
• Support Opportunities: Research Grants - Young Investigators Grants