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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise Deactivates Leukocytes in Asthma

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Author(s):
Vieira, R. P. [1] ; Silva, R. A. [2] ; Oliveira-Junior, M. C. [1] ; Greiffo, F. R. [1] ; Ligeiro-Oliveira, A. P. [1] ; Martins, M. A. [3] ; Carvalho, C. R. F. [2]
Total Authors: 7
Affiliation:
[1] Nove de Julho Univ, BR-01504001 Sao Paulo - Brazil
[2] Univ Sao Paulo, Phys Therapy LIM 34, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Clin Med LIM 20, BR-05508 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 35, n. 7, p. 629-635, JUN 2014.
Web of Science Citations: 15
Abstract

Leukocytes play a central role in asthma physiopathology. Aerobic training (AT) reduces leukocytes recruitment to the airways, but the effects of AT on some aspects of leukocytes activation in asthma are unknown. Therefore, the effects of 4 weeks of AT on airway inflammation, pulmonary and systemic Th2 cytokines levels, leukocytes expression of pro and anti-infl ammatory, profibrotic, oxidants and anti-oxidants mediators in an experimental model of asthma was investigated. AT reduced the levels of IL-4, IL-5, IL-13 in bronchoalveolar lavage fluid (BALF) (p < 0.001), serum levels of IL-5, while increased BALF and serum levels of IL-10 (p < 0.001). In addition, AT reduced leukocytes activation, showed through decreased expression of Th2 cytokines (IL-4, IL-5, IL-13; p < 0.001), chemokines (CCL5, CCL10; p < 0.001), adhesion molecules (VCAM-1, ICAM1; p < 0.05), reactive oxygen and nitrogen species (GP91phox and 3-nitrotyrosine; p < 0.001), inducible nitric oxide synthase (iNOS; p < 0.001), nuclear factor kB (NF-kB; p < 0.001) while increased the expression of anti-infl ammatory cytokine (IL-10; p < 0.001). AT also decreased the expression of growth factors (TGF-beta, IGF-1, VEGF and EGFr; p < 0.001). We conclude that AT reduces the activation of peribronchial leukocytes in a mouse model of allergic asthma, resulting in decreased airway inflammation and Th2 response. (AU)

FAPESP's process: 05/04413-1 - Effect of physical aerobic training in asthma: evaluation in experimental models
Grantee:Celso Ricardo Fernandes de Carvalho
Support Opportunities: Regular Research Grants