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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lung age is related to carotid structural alterations in hypertensive subjects

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Author(s):
Kiyota, Tatiana A. [1] ; Mendes, Paulo R. [1] ; Cipolli, Jose A. [1] ; Schreiber, Roberto [1] ; Paim, Layde R. [1] ; Bellinazzi, Vera R. [1] ; Matos-Souza, Jose R. [1] ; Sposito, Andrei C. [1] ; Nadruz, Jr., Wilson [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13081970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION; v. 8, n. 6, p. 381-387, JUN 2014.
Web of Science Citations: 0
Abstract

Hypertensive patients exhibit higher cardiovascular risk and reduced lung function compared with the general population. Whether this association stems from the coexistence of two highly prevalent diseases or from direct or indirect links of pathophysiological mechanisms is presently unclear. This study investigated the association between lung function and carotid features in non-smoking hypertensive subjects with supposed normal lung function. Hypertensive patients (n = 67) were cross-sectionally evaluated by clinical, hemodynamic, laboratory, and carotid ultrasound analysis. Forced vital capacity, forced expired volume in 1 second and in 6 seconds, and lung age were estimated by spirometry. Subjects with ventilatory abnormalities according to current guidelines were excluded. Regression analysis adjusted for age and prior smoking history showed that lung age and the percentage of predicted spirometric parameters associated with common carotid intima-media thickness, diameter, and stiffness. Further analyses, adjusted for additional potential confounders, revealed that lung age was the spirometric parameter exhibiting the most significant regression coefficients with carotid features. Conversely, plasma Creactive protein and matrix-metalloproteinases-2/9 levels did not influence this relationship. The present findings point toward lung age as a potential marker of vascular remodeling and indicate that lung and vascular remodeling might share common pathophysiological mechanisms in hypertensive subjects. (C) 2014 American Society of Hypertension. All rights reserved. (AU)

FAPESP's process: 10/16252-0 - Mechanisms related to increased cardiovascular risk in spinal cord injury subjects
Grantee:Wilson Nadruz Junior
Support Opportunities: Regular Research Grants