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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effects of paradoxical sleep deprivation on amphetamine-induced behavioral sensitization in adult and adolescent mice

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Author(s):
Kameda, Sonia R. [1, 2] ; Fukushiro, Daniela F. [2] ; Trombin, Thais F. [2] ; Sanday, Leandro [2] ; Wuo-Silva, Raphael [2] ; Saito, Luis R. [1] ; Tufik, Sergio [1] ; D'Almeida, Vania [1] ; Frussa-Filho, Roberto [1, 2]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pharmacol, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 218, n. 3, p. 335-340, AUG 30 2014.
Web of Science Citations: 1
Abstract

Drug-induced behavioral sensitization (BS), paradoxical sleep deprivation (PSD) and adolescence in rodents are associated with changes in the mesolimbic dopaminergic system. We compared the effects of PSD on amphetamine-induced BS in adult and adolescent mice. Adult (90 days old) and adolescent (45 days old) Swiss mice were subjected to PSD for 48 h. Immediately after PSD, mice received saline or 2.0 mg/kg amphetamine intraperitoneally (i.p.), and their locomotion was quantified in activity chambers. Seven days later, all the animals were challenged with 2.0 mg/kg amphetamine i.p., and their locomotion was quantified again. Acute amphetamine enhanced locomotion in both adult and adolescent mice, but BS was observed only in adolescent mice. Immediately after its termination, PSD decreased locomotion of both saline- and amphetamine-treated adolescent mice. Seven days later, previous PSD potentiated both the acute stimulatory effect of amphetamine and its sensitization in adolescent mice. In adult animals, previous PSD revealed BS. Our data suggest that adolescent mice are more vulnerable to both the immediate and long-term effects of PSD on amphetamine-induced locomotion. Because drug-induced BS in rodents shares neuroplastic changes with drug craving in humans, our findings also suggest that both adolescence and PSD could facilitate craving-related mechanisms in amphetamine abuse. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)