Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mantle cell lymphoma harboring Burkitt's-like translocations presents differential expression of aurora kinase genes compared with others 8q abnormalities

Full text
Author(s):
de Oliveira, Fabio Morato [1] ; Nunes Rodrigues-Alves, Ana Paula [1] ; Lucena-Araujo, Antonio Roberto [1] ; Silva, Ferdinando de Paula [1] ; da Silva, Fernanda Borges [1] ; Falcao, Roberto Passetto [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MEDICAL ONCOLOGY; v. 31, n. 5 MAY 2014.
Web of Science Citations: 0
Abstract

We compared the levels of AURKA and AURKB in 24 (mantle cell lymphoma) MCL patients harboring 8q abnormalities and its relationship with MYCC gene status. Two distinct subgroups were observed, in terms of MYCC expression. Except for the patients with Burkitt'slike translocation, none of the patients harboring 8q abnormalities, including balanced translocations or duplications of MYCC band, identified both by G-banding and SKY, showed differential expression levels of MYCC. These previous findings also reflected in the differential expression of AURKA and AURKB genes. We found that AURKA and AURKB mRNA were expressed at significantly higher levels in MCL patients harboring Burkitt'slike translocation, when compared to patients with 8q rearrangements. The high expression of aurora kinase genes is reported to be associated with some parameters of clinical oncologic aggressiveness, such as high histological grade, invasion and increased rates of metastasis in several types of cancers. It is possible that in MCL patients expressing abnormal levels of MYCC together with a high expression of AURKA might offer some resistant to the conventional therapy purposes. Thus, aurora kinase inhibitors may also be considered for this specific subgroup on MCL, whose aggressive clinical course resembles high-grade lymphoma. (AU)

FAPESP's process: 11/01647-2 - Evaluation of genomic instability by analysis of the nuclear three-dimensional organization of telomeres in myelodysplastic syndrome (MDS)
Grantee:Fábio Morato de Oliveira
Support Opportunities: Research Grants - Young Investigators Grants