Prognostic Determinants of Patients with Chronic Systolic Heart Failure Secondary to Systemic Arterial Hypertension

Author(s)

Rolande, Dalva M. S. ^[1] ; Fantini, Joao Paulo ^[1] ; Neto, Augusto Cardinalli ^[1] ; Cordeiro, Jose A. ^[1] ; Bestetti, Reinaldo B. ^[1]

Affiliation

^[1] Hosp Base Sao Jose Rio Preto, Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Arquivos Brasileiros de Cardiologia; v. 98, n. 1, p. 76-82, JAN 2012.
• Web of Science Citations: 7

Abstract

Background: Systemic arterial hypertension (SAH) is an important cause of chronic systolic heart failure (CHF) in underdeveloped countries. It would be desirable to know predictors of mortality for patients with this condition in order to provide proper scientific treatment. Objective: To determine risk factors for all-cause mortality in patients with CHF secondary to SAH in the current era of heart failure therapy for left ventricular systolic dysfunction. Methods: All patients routinely and prospectively followed at the Cardiomyopathy Clinic of our Institution from January, 2000 to April, 2008 with the diagnosis of CHF secondary to SAH were screened for the study. Cox proportional hazards model was used to establish independent predictors of all-cause mortality. Results: One hundred thirty patients were included; 74 (57%) were male. Thirty one (24%) patients died, 5 (4%) underwent heart transplantation, and 94 (72%) were alive at study end. Survival probability at 12, 24, 36, 48, and 60 months was 96%, 93%, 84%, 79%, and 76%, respectively. Age (Hazard Ratio=1,05, 95% Confidence Interval 95% 1,01 to 1,08, p value=0,01), left ventricular diastolic dimension (Hazard Ratio=1,08; 95% Confidence Interval 1,02 to 1,09; p value=0,003), and B-Blocker therapy (Hazard Ratio=0,41; 95% Confidence Interval 0,19 to 0,86; p value=0,02) were found to be independent predictors of mortality. Conclusion: Age, left ventricular diastolic dimension and underuse of Beta-Blocker therapy were independent predictors of mortality for patients with CHF secondary to SAH in the population studied. (Arq Bras Cardiol 2012;98(1):76-83) (AU)

• FAPESP's process: 09/11310-5 - Prognostic determinants of chronic systolic heart failure secondary to hypertensive cardiopaty in the contemporary era of chronic heart failure treatment
• Grantee: João Paulo Pretti Fantin
• Support Opportunities: Scholarships in Brazil - Scientific Initiation