| Full text | |
| Author(s): |
Rossi, Marcos A.
[1]
;
Tanowitz, Herbert B.
[2]
;
Malvestio, Lygia M.
[1]
;
Celes, Mara R.
[1]
;
Campos, Erica C.
[1]
;
Blefari, Valdecir
[1]
;
Prado, Cibele M.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Lab Cellular & Mol Cardiol, Dept Pathol, Sao Paulo - Brazil
[2] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 - USA
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | PLoS Neglected Tropical Diseases; v. 4, n. 8 AUG 2010. |
| Web of Science Citations: | 40 |
| Abstract | |
This review focuses on the short and bewildered history of Brazilian scientist Carlos Chagas's discovery and subsequent developments, the anatomopathological features of chronic Chagas cardiomyopathy (CCC), an overview on the controversies surrounding theories concerning its pathogenesis, and studies that support the microvascular hypothesis to further explain the pathological features and clinical course of CCC. It is our belief that knowledge of this particular and remarkable cardiomyopathy will shed light not only on the microvascular involvement of its pathogenesis, but also on the pathogenetic processes of other cardiomyopathies, which will hopefully provide a better understanding of the various changes that may lead to an end-stage heart disease with similar features. This review is written to celebrate the 100th anniversary of the discovery of Chagas disease. (AU) | |
| FAPESP's process: | 06/59618-0 - O possível papel do complexo de glicoproteínas associadas à distrofia na morte súbita na tripanossomiase americana experimental |
| Grantee: | Marcos Antonio Rossi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/52556-1 - Imunopatogênese da lesão periapical experimentalmente induzida em camundongos knockout de citocinas Th1 (IFNy) e Th2 (IL-4 and IL-10), molécula de adesão intercelular (ICAM-1) e receptor de quimiocina (CCR5): panorama geral de possíveis mecanismos envolvidos no estímulo ou proteção da reabsorção óssea |
| Grantee: | Marcos Antonio Rossi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 06/52882-3 - O possível papel do complexo de glicoproteínas associadas à distrofina na morte súbita na tripanosomíase americana experimental |
| Grantee: | Cibele Maria Prado Zinni |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 08/00954-6 - Possible role of dystrophin and integrin-associated glycoprotein complex in sudden death in experimental Chagas disease |
| Grantee: | Cibele Maria Prado Zinni |
| Support Opportunities: | Scholarships abroad - Research |