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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

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Author(s):
Reis, Wagner L. [1, 2, 3] ; Saad, Wilson A. [4] ; Camargo, Luiz A. [4] ; Elias, Lucila L. K. [4] ; Antunes-Rodrigues, Jose [1]
Total Authors: 5
Affiliation:
[1] Paulista State Univ Araraquara, UNESP, Sch Dent, Dept Physiol, Araraquara, SP - Brazil
[2] Univ Taubate UNITAU, Basic Inst Biosci, Taubate, SP - Brazil
[3] Centro Univ Araraquara, Dept Exact & Nat Sci, Araraquara, SP - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Neuroendocrinol Lab, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Behavioral and Brain Functions; v. 6, OCT 25 2010.
Web of Science Citations: 19
Abstract

Background: Nitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia. Neuroendocrine and cardiovascular responses, drinking behavior, and urinary excretions were examined following central angiotensinergic stimulation in awake freely-moving rats pretreated with intracerebroventricular injections of N omega-nitro-L-arginine methyl ester (L-NAME, 40 mu g), an inhibitor of NO synthase, and L-arginine (20 ug), a precursor of NO. Results: Injections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume. L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II. Discussion and conclusion: Thus, the central nitrergic system participates in the angiotensinergic responses evoked by water deprivation and hypovolemia to refrain neurohypophysial secretion, hydromineral balance, and blood pressure homeostasis. (AU)

FAPESP's process: 98/15846-0 - Neuroendocrine control of hydrolectric equilibrium
Grantee:José Antunes Rodrigues
Support Opportunities: Research Projects - Thematic Grants