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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modifiable factors of vitamin D status among a Brazilian osteoporotic population attended a public outpatient clinic

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Author(s):
Marília Brasilio Rodrigues Camargo [1] ; llda Sizue Kunii [2] ; Lilian Fukusima Hayashi [2] ; Patrícia Muszkat [4] ; Catherine Gusman Anelli [2] ; Rosângela Villa Marin-Mio [6] ; Lígia Araújo Martini [7] ; Natasha França [8] ; Marise Lazaretti-Castro [2]
Total Authors: 9
Affiliation:
[1] Federal University of São Paulo. School of Medicine. Division of Endocrinology - Brasil
[2] Univ Fed Sao Paulo Unifesp, Sch Med, Div Endocrinol, Sao Paulo - Brazil
[3] Federal University of São Paulo. School of Medicine. Division of Endocrinology - Brasil
[4] Federal University of São Paulo. School of Medicine. Division of Endocrinology - Brasil
[5] University of São Paulo. Faculty of Public Health. Department of Nutrition - Brasil
[6] University of São Paulo. Faculty of Public Health. Department of Nutrition - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 58, n. 5, p. 572-582, 2014-07-00.
Abstract

Objectives To evaluate the serum 25-hydroxyvitamin D [25(OH)D] concentration in Brazilian osteoporotic patients and the modifiable factors of vitamin D status in this population. Subjects and methods In a cross-sectional study, 363 community-dwelling patients who sought specialized medical care were evaluated between autumn and spring in São Paulo, Brazil. Serum levels of 25(OH)D and parathormone (PTH), biochemical and anthropometric measurements, and bone density scans were obtained. The group was assessed using two questionnaires: one questionnaire covered lifestyle and dietary habits, skin phototype, sun exposure, medical conditions, and levels of vitamin D supplementation (cholecalciferol); the other questionnaire assessed health-related quality-of-life. Logistic regression and a decision tree were used to assess the association between the variables and the adequacy of vitamin D status. Results The mean age of the overall sample was 67.9 ± 8.6 years, and the mean 25(OH)D concentration was 24.8 ng/mL. The prevalence of inadequate vitamin D status was high (73.3%), although 81.5% of the subjects were receiving cholecalciferol (mean dose of 8,169 IU/week). 25(OH)D was positively correlated with femoral neck bone mineral density and negatively correlated with PTH. In the multivariate analysis, the dose of cholecalciferol, engagement in physical activity and the month of the year (September) were associated with improvement in vitamin D status. Conclusions In this osteoporotic population, vitamin D supplementation of 7,000 IU/week is not enough to reach the desired 25(OH)D concentration (≥ 30 ng/mL). Engagement in physical activity and the month of the year are modifiable factors of the vitamin D status in this population. (AU)

FAPESP's process: 08/55567-7 - Vitamin D status in patients with Osteoporosis treated in the ambulatory of bone metabolic diseases at a university hospital in the city of São Paulo and evaluation of intestinal calcium absorption
Grantee:Marise Lazaretti Castro
Support Opportunities: Regular Research Grants