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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues

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Author(s):
Coqueiro, Aline [1, 2] ; Regasini, Luis Octavio [1] ; Stapleton, Paul [2] ; Bolzani, Vanderlan da Silva [1] ; Gibbons, Simon [2]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara - Brazil
[2] UCL Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX - England
Total Affiliations: 2
Document type: Journal article
Source: Journal of Natural Products; v. 77, n. 8, p. 1972-1975, AUG 2014.
Web of Science Citations: 12
Abstract

The present investigation deals with the antibiotic activity of eight natural guanidine alkaloids and two synthetic analogues against a variety of clinically relevant methicillin-resistant Staphylococcus aureus strains. Galegine (1) and pterogynidine (2) were the most potent compounds, with a minimum inhibitory concentration of 4 mg/L, to all tested strains. The preliminary chemical features correlating to anti-MRSA activity showed that the size of the side chain and the substitution pattern in the guanidine core played a key role in the antibacterial activity of the imino group. Guanidine alkaloids 1 and 2 are promising molecular models for further synthetic derivatives and, thus, for medicinal chemistry studies. (AU)

FAPESP's process: 06/61187-7 - Bioguided fractionation for selection of potential antioxidant, antimalarial and antibiotic substances in Kielmeyera variabilis (Clusiaceae) and Brosimum glaziovii (Moraceae) species
Grantee:Aline Coqueiro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 03/00886-7 - Phytochemical study of Pterogyne nitens (Leguminosae), synthesis and pharmacological evaluation of natural guandine alkaloids and of potential antitumoral analogues
Grantee:Luis Octávio Regasini
Support type: Scholarships in Brazil - Doctorate (Direct)