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Pan-resistoma de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil

Processo: 16/08593-9
Modalidade de apoio:Auxílio à Pesquisa - Regular
Data de Início da vigência: 01 de outubro de 2016
Data de Término da vigência: 30 de novembro de 2018
Área do conhecimento:Ciências Biológicas - Microbiologia - Microbiologia Aplicada
Pesquisador responsável:Nilton Erbet Lincopan Huenuman
Beneficiário:Nilton Erbet Lincopan Huenuman
Instituição Sede: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brasil
Assunto(s):Microbiologia médica  Plasmídeos  Farmacorresistência bacteriana 
Palavra(s)-Chave do Pesquisador:Beta-Lactamases (CTX-M) | Carbapenemases (KPC-2) | Gram-Negativos | plasmids | Resistência Bacteriana | resistoma | Microbiologia Médica

Resumo

A resistência aos antimicrobianos entre patógenos de importância clínica, humana e veterinária, é um desafio à saúde pública mundial, onde a disseminação dos determinantes genéticos pode ocorrer de forma dinâmica do ambiente hospitalare para o meio externo e vice-versa. De fato, linhagens de bactérias patogênicas multirresistentes (MRs) podem disseminar-se entre animais e humanos, bem como entre os diferentes ecossistemas. Por outro lado, elementos que mobilizam genes de resistência podem ser transferidos horizontalmente entre patógenos e a microbiota comensal, favorecendo a adaptação e endemicidade de complexos clonais (CC) considerados de alto risco. A epidemiologia, controle e manejo das infecções causadas por bactérias MRs, assim como, a descoberta e desenvolvimento de novos agentes antimicrobianos podem ser favorecidos pela análise dos genomas e genótipos de resistência "resistoma", obtidos por métodos de sequenciamento de nova geração (NGS). O presente projeto de pesquisa visa à obtenção de um banco de dados de sequências que permita a análise bioinformática do pan-resistoma de cepas de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil, isoladas de amostras humanas, veterinárias e do ambiente. Os resultados contribuirão para a criação de uma plataforma de seqüências de referência que poderá ser utilizada para fim diagnóstico, terapêutico e/ou controle epidemiológico, entre outros; elucidando "a priori" aspectos genéticos de adaptação, resistência e virulência de clones endêmicos. (AU)

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Publicações científicas (57)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; CARVALHO, MARCELO P. N.; LINCOPAN, NILTON. Extended-spectrum-beta-lactamase (CTX-M)-producing Escherichia coli in wild fishes from a polluted area in the Atlantic Coast of South America. Marine Pollution Bulletin, v. 135, p. 183-186, . (16/08593-9)
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; CUNHA, MARCOS P. V.; LOPES, RALF; CERDEIRA, LOUISE; LINCOPAN, NILTON. Emergence of CTX-M-27-producing Escherichia coli of ST131 and clade C1-M27 in an impacted ecosystem with international maritime traffic in South America. Journal of Antimicrobial Chemotherapy, v. 75, n. 6, p. 1647-1649, . (15/13527-2, 16/08593-9, 14/11523-7)
SACRAMENTO, ANDREY G.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; DOLABELLA, SILVIO S.; ZANELLA, ROSEMEIRE C.; CERDEIRA, LOUISE; LINCOPAN, NILTON. VanA-type vancomycin-resistant Enterococcus faecium ST1336 isolated from mussels in an anthropogenically impacted ecosystem. Marine Pollution Bulletin, v. 142, p. 533-536, . (16/08593-9)
GOLDBERG, DAPHNE W.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; COSTA, DANIELA G. C.; LOUREIRO BRACARENSE, ANA PAULA; LINCOPAN, NILTON. Genetic background of CTX-M-15-producing Enterobacter hormaechei ST114 and Citrobacter freundii ST265 co-infecting a free-living green turtle (Chelonia mydas). ZOONOSES AND PUBLIC HEALTH, v. 66, n. 5, p. 540-545, . (15/13527-2, 16/08593-9)
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; MOURA, QUEZIA; ESPOSITO, FERNANDA; SABINO, CAETANO P.; LINCOPAN, NILTON. Identification and genomic features of halotolerant extended-spectrum-beta-lactamase (CTX-M)-producing Escherichia coli in urban-impacted coastal waters, Southeast Brazil. Marine Pollution Bulletin, v. 150, . (15/13527-2, 16/08593-9, 16/03044-7)
LOPES, RALF; CERDEIRA, LOUISE T.; FERNANDES, MIRIAM R.; PEREZ-CHAPARRO, PAULA J.; MCCULLOCH, JOHN A.; LINCOPAN, NILTON. Draft genome sequence of a CTX-M-15-producing endophytic Klebsiella pneumoniae ST198 isolate from commercial lettuce. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 10, p. 19-20, . (16/08593-9)
CERDEIRA, LOUISE T.; CUNHA, MARCOS P. V.; FRANCISCO, GABRIELA R.; BUENO, MARIA FERNANDA C.; ARAUJO, BRUNA F.; RIBAS, ROSINEIDE M.; GONTIJO-FILHO, PAULO P.; KNOBL, TEREZINHA; GARCIA, DOROTI DE OLIVEIRA; LINCOPAN, NILTON. IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 89, n. 2, p. 164-167, . (16/08593-9)
FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; SILVA, MEIRE M.; SELLERA, FABIO P.; MUNOZ, MARIA; JUNIOR, FELICIO G.; AZEVEDO, SERGIO S.; POWER, PABLO; GUTKIND, GABRIEL; LINCOPAN, NILTON. Novel mcr-5.3 variant in a CTX-M-8-producing Escherichia coli ST711 isolated from an infected horse. Journal of Antimicrobial Chemotherapy, v. 73, n. 12, p. 3520-3522, . (16/08593-9, 15/21325-0, 15/13527-2)
FUENTES-CASTILLO, DANNY; FARFAN-LOPEZ, MARIELLA; ESPOSITO, FERNANDA; MOURA, QUEZIA; FERNANDES, MIRIAM R.; LOPES, RALF; CARDOSO, BRENDA; MUNOZ, MARIA E.; CERDEIRA, LOUISE; NAJLE, IGNACIA; et al. Wild owls colonized by international clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli and Salmonella Infantis in the Southern Cone of America. Science of The Total Environment, v. 674, p. 554-562, . (16/08593-9)
MOURA, QUEZIA; CERDEIRA, LOUISE; FERNANDES, MIRIAM R.; VIANELLO, MARCO A.; LINCOPAN, NILTON. Novel class 1 integron (In1390) harboring bla(GES)(-5) in a Morganella morganii strain recovered from a remote community. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 91, n. 4, p. 345-347, . (16/08593-9)
MOURA, QUEZIA; FERNANDES, MIRIAM R.; SILVA, KETRIN C.; MONTE, DANIEL F.; ESPOSITO, FERNANDA; DROPA, MILENA; NORONHA, CESAR; MORENO, ANDREA M.; LANDGRAF, MARIZA; NEGRAO, FABIO J.; et al. Virulent nontyphoidal Salmonella producing CTX-M and CMY-2 beta-lactamases from livestock, food and human infection, Brazil. VIRULENCE, v. 9, n. 1, p. 281-286, . (16/08593-9)
MONTE, DANIEL FARIAS; MEM, ANDRESSA; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; ESPOSITO, FERNANDA; GALVAO, JULIA A.; FRANCO, BERNADETTE D. G. M.; LINCOPAN, NILTON; LANDGRAF, MARIZA. Chicken Meat as a Reservoir of Colistin-Resistant Escherichia coli Strains Carrying mcr-1 Genes in South America. Antimicrobial Agents and Chemotherapy, v. 61, n. 5, . (16/08593-9, 13/07914-8)
TURANO, HELENA; GOMES, FERNANDO; BARROS-CARVALHO, GESIELE A.; LOPES, RALF; CERDEIRA, LOUISE; NETTO, LUIS E. S.; GALES, ANA C.; LINCOPAN, NILTON. Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, v. 61, n. 5, . (16/08593-9)
MOURA, QUEZIA; ESPOSITO, FERNANDA; FERNANDES, MIRIAM R.; ESPINOZA-MUNOZ, MARIA; SOUZA, TIAGO A.; SANTOS, SILVIA R.; CERDEIRA, LOUISE; CASSETTARI, VALERIA; LINCOPAN, NILTON. Genome sequence analysis of a hypermucoviscous/hypervirulent and MDR CTX-M-15/K19/ST29 Klebsiella pneumoniae isolated from human infection. PATHOGENS AND DISEASE, v. 75, n. 9, . (16/08593-9)
SELLERA, ABIO P.; FERNANDES, MIRIAM R.; RUIZ, REGINA; FALLEIROS, ANA C. M.; RODRIGUES, FERNANDA P.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Identification of KPC-2-producing Escherichia coli in a companion animal: a new challenge for veterinary clinicians. Journal of Antimicrobial Chemotherapy, v. 73, n. 8, p. 2259-2261, . (16/08593-9, 15/21325-0, 15/13527-2)
MOHSIN, MASHKOOR; AZAM, MARIYA; RAHMAN, SAJJAD UR; ESPOSITO, FERNANDA; SELLERA, FABIO P.; MONTE, DANIEL F.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Genomic background of a colistin-resistant and highly virulent MCR-1-positive Escherichia coli ST6395 from a broiler chicken in Pakistan. PATHOGENS AND DISEASE, v. 77, n. 7, . (16/08593-9, 19/15578-4)
ZAMPARETTE, CAETANA P.; SCHORNER, MARCOS; CAMPOS, ELIZANDRA; MOURA, QUEZIA; CERDEIRA, LOUISE; TARTARI, DANIELA C.; SEREIA, ALINE F. R.; CUNHA, PATRICIA; FONTANA, HERRISON; DE OLIVEIRA, LUIZ FELIPE V.; et al. IncX4 Plasmid-Mediated mcr-1.1 in Polymyxin-Resistant Escherichia coli from Outpatients in Santa Catarina, Southern Brazil. MICROBIAL DRUG RESISTANCE, v. 26, n. 11, . (16/08593-9)
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; SOUZA, TIAGO A.; NASCIMENTO, CRISTIANE L.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft genome sequence of an extensively drug-resistant Pseudomonas aeruginosa isolate belonging to ST644 isolated from a footpad infection in a Magellanic penguin (Spheniscus magellanicus). JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 12, p. 88-89, . (16/08593-9, 15/13527-2)
NASCIMENTO, TATIANE; CANTAMESSA, RODRIGO; MELO, LUANA; FERNANDES, MIRIAM R.; FRAGA, EDMIR; DROPA, MILENA; SATO, MARIA I. Z.; CERDEIRA, LOUISE; LINCOPAN, NILTON. International high-risk clones of Klebsiella pneumoniae KPC-2/CC258 and Escherichia coli CTX-M-15/CC10 in urban lake waters. Science of The Total Environment, v. 598, p. 910-915, . (12/23588-0, 16/08593-9, 13/04725-0)
LOPES, RALF; FUENTES-CASTILLO, DANNY; FONTANA, HERRISON; RODRIGUES, LARISSA; DANTAS, KARINE; CERDEIRA, LOUISE; HENRIQUES, ISABEL; LINCOPAN, NILTON. Endophytic Lifestyle of Global Clones of Extended-Spectrum beta-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?. MSYSTEMS, v. 6, n. 1, . (16/08593-9, 15/21325-0)
SARTORI, LUCIANA; SELLERA, FABIO P.; MOURA, QUEZIA; CARDOSO, BRENDA; FONTANA, HERRISON; CORTES, LUCAS A.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Genomic features of a polymyxin-resistant Klebsiella pneumoniae ST491 isolate co-harbouring bla(CTX-M-8) and qnrE1 genes from a hospitalised cat in Sao Paulo, Brazil. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 21, p. 186-187, . (16/08593-9)
FERREIRA, THALITA C. S.; SAUTER, ISMAEL P.; BORDA-SAMPER, LINA; BENTIVOGLIO, ENYD; DAMATA, JARINA P.; TANIWAKI, NOEMI N.; ORREGO, PATRICIO R.; ARAYA, JORGE E.; LINCOPAN, NILTON; CORTEZ, MAURO. Effect of DODAB Nano-Sized Cationic Bilayer Fragments against Leishmania amazonensis. Molecules, v. 25, n. 23, . (13/14087-0, 13/15254-8, 16/08593-9, 12/24105-3)
RUEDA FURLAN, JOAO PEDRO; MOURA, QUEZIA; LIMA GONZALEZ, IRYS HANY; RAMOS, PATRICIA LOCOSQUE; LINCOPAN, NILTON; STEHLING, ELIANA GUEDES. Draft genome sequence of a multidrug-resistant CTX-M-65-producing Escherichia coli ST156 colonizing a giant anteater (Myrmecophaga tridactyla) in a Zoo. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 17, p. 2-pg., . (16/08593-9, 18/19539-0)
SILVA, MEIRE M.; SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; GARINO, FELICIO; AZEVEDO, SERGIO S.; LINCOPAN, NILTON. Genomic features of a highly virulent, ceftiofur-resistant, CTX-M-8-producing Escherichia coli ST224 causing fatal infection in a domestic cat. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 15, p. 2-pg., . (16/08593-9, 15/13527-2)
TAMARIZ, JESUS; LLANOS, CARLOS; SEAS, CARLOS; MONTENEGRO, PAOLA; LAGOS, JOSE; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft Genome Sequence of the First New Delhi Metallo-beta-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru. GENOME ANNOUNCEMENTS, v. 6, n. 13, p. 2-pg., . (16/08593-9)
SARTORI, LUCIANA; SELLERA, FABIO P.; MOURA, QUEZIA; CARDOSO, BRENDA; CERDEIRA, LOUISE; LINCOPAN, NILTON. Multidrug-resistant CTX-M-15-positive Klebsiella pneumoniae ST307 causing urinary tract infection in a dog in Brazil. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 19, p. 2-pg., . (16/08593-9, 15/13527-2)
SARTORI, LUCIANA; FERNANDES, MIRIAM R.; IENNE, SUSAN; DE SOUZA, TIAGO A.; GREGORY, LILIAN; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft genome sequences of two fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST90 (ST23 complex) isolated from a calf and a dairy cow in South America. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 11, p. 3-pg., . (16/08593-9)
MELO, LUANA C.; HAENNI, MARISA; SARAS, ESTELLE; CERDEIRA, LOUISE; MOURA, QUEZIA; BOULOUIS, HENRI-JEAN; MADEC, JEAN-YVES; LINCOPAN, NILTON. Genomic characterisation of a multidrug-resistant TEM-52b extended-spectrum beta-lactamase-positive Escherichia coli ST219 isolated from a cat in France. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 18, p. 2-pg., . (16/08593-9)
SELLERA, FABIO P.; FUGA, BRUNA; FONTANA, HERRISON; ESPOSITO, FERNANDA; CARDOSO, BRENDA; KONNO, SIBELE; BERL, CARLA; CAPPELLANES, MARIANA H.; CORTEZ, MARCIA; IKEDA, MARCELO; et al. Detection of IncN-pST15 one-health plasmid harbouring bla(KPC-2) in a hypermucoviscous Klebsiella pneumoniae CG258 isolated from an infected dog, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, . (16/08593-9)
TAMARIZ, JESUS; LLANOS, CARLOS; SEAS, CARLOS; MONTENEGRO, PAOLA; LAGOS, JOSE; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft Genome Sequence of the First New Delhi Metallo-beta-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 13, . (16/08593-9)
DE CARVALHO, MARCELO P. N.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; LOPES, RALF; MONTE, DANIEL F.; HIPPOLITO, ALICIA G.; MILANELO, LILIANE; RASO, TANIA F.; LINCOPAN, NILTON. International clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, v. 67, n. 5, p. 1804-1815, . (15/13527-2, 16/03044-7, 16/08593-9)
CERDEIRA, LOUISE; MONTE, DANIEL F. M.; FUGA, BRUNA; SELLERA, FABIO P.; NEVES, INGRITH; RODRIGUES, LARISSA; LANDGRAF, MARIZA; LINCOPAN, NILTON. Genomic insights of Klebsiella pneumoniae isolated from a native Amazonian fish reveal wide resistome against heavy metals, disinfectants, and clinically relevant antibiotics. Genomics, v. 112, n. 6, p. 5143-5146, . (16/03044-7, 16/08593-9)
DOS ANJOS, CAROLINA; SABINO, CAETANO P.; BUERIS, VANESSA; FERNANDES, MIRIAM R.; POGLIANI, FABIO C.; LINCOPAN, NILTON; SELLERA, FABIO P.. Antimicrobial blue light inactivation of international clones of multidrug-resistant Escherichia coli ST10, ST131 and ST648. Photodiagnosis and Photodynamic Therapy, v. 27, p. 51-53, . (15/13527-2, 16/08593-9, 16/25095-2)
ESPOSITO, FERNANDA; FERNANDES, MIRIAM R.; LOPES, RALF; MUNOZ, MARIA; SABINO, CAETANO P.; CUNHA, MARCOS P.; SILVA, KETRIN C.; CAYO, RODRIGO; MARTINS, WILLAMES M. B. S.; MORENO, ANDREA M.; et al. Detection of Colistin-Resistant MCR-1-Positive Escherichia coli by Use of Assays Based on Inhibition by EDTA and Zeta Potential. Journal of Clinical Microbiology, v. 55, n. 12, p. 3454-3465, . (16/08593-9, 15/13527-2)
VALENCIA-BACCA, JUAN; SILVA, MEIRE M.; CERDEIRA, LOUISE; ESPOSITO, FERNANDA; CARDOSO, BRENDA; MUNOZ, MARIA E.; JIMENEZ-VILLEGAS, TATIANA; CARDENAS-ARIAS, ADRIANA; PESSOA, DANIELLE A. N.; LINCOPAN, NILTON. Detection and Whole-Genome Analysis of a High-Risk Clone of Klebsiella pneumoniae ST340/CG258 Producing CTX-M-15 in a Companion Animal. MICROBIAL DRUG RESISTANCE, v. 26, n. 6, . (16/08593-9)
DOS ANJOS, C.; SELLERA, F. P.; DE FREITAS, L. M.; GARGANO, R. G.; TELLES, E. O.; FREITAS, R. O.; BAPTISTA, M. S.; RIBEIRO, M. S.; LINCOPAN, N.; POGLIANI, F. C.; et al. Inactivation of milk-borne pathogens by blue light exposure. JOURNAL OF DAIRY SCIENCE, v. 103, n. 2, p. 1261-1268, . (16/08593-9, 13/07937-8)
CERDEIRA, LOUISE T.; LAM, MARGARET M. C.; WYRES, KELLY L.; WICK, RYAN R.; JUDD, LOUISE M.; LOPES, RALF; RIBAS, ROSINEIDE M.; MORAIS, MARCIA M.; HOLT, KATHRYN E.; LINCOPAN, NILTON. Small IncQ1 and Col-Like Plasmids Harboring bla(KPC-2) and Non-Tn4401 Elements (NTEKPC-IId) in High-Risk Lineages of Klebsiella pneumoniae CG258. Antimicrobial Agents and Chemotherapy, v. 63, n. 3, . (16/08593-9, 15/21325-0, 17/25909-2)
SELLERA, FABIO P.; LINCOPAN, NILTON. Zooanthroponotic transmission of high-risk multidrug-resistant pathogens: A neglected public health issue. JOURNAL OF INFECTION AND PUBLIC HEALTH, v. 12, n. 2, p. 294-295, . (16/08593-9)
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; SABINO, CAETANO P.; DE FREITAS, LAURA M.; DA SILVA, LUCIANO C. B. A.; POGLIANI, FABIO C.; RIBEIRO, MARTHA S.; HAMBLIN, MICHAEL R.; LINCOPAN, NILTON. Effective treatment and decolonization of a dog infected with carbapenemase (VIM-2)-producing Pseudomonas aeruginosa using probiotic and photodynamic therapies. VETERINARY DERMATOLOGY, v. 30, n. 2, p. 170+, . (14/24581-5, 16/08593-9, 15/13527-2)
OLIVEIRA, FLAVIO A.; ZACCARIOTTO, TANIA R.; PIVETA, CRISTIANE; HOFLING, CHRISTIAN C.; RESENDE, MARIANGELA R.; LEVY, CARLOS E.; ESPOSITO, FERNANDA; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; LINCOPAN, NILTON. MCR-1-positive colistin-resistant Escherichia coli in immunocompromised hospitalised patients. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 52, n. 3, p. 438-440, . (16/08593-9)
SILVA, MEIRE M.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; CERDEIRA, LOUISE; MEDEIROS, LYLIAN K. G.; GARINO, FELICIO; AZEVEDO, SERGIO S.; LINCOPAN, NILTON. Multidrug-resistant CDX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 92, n. 3, p. 259-261, . (16/08593-9)
OPAZO-CAPURRO, ANDRES; SAN MARTIN, IVAN; QUEZADA-AGUILUZ, MARIO; MORALES-LEON, FELIPE; DOMINGUEZ-YEVENES, MARIANA; LIMA, CELIA A.; ESPOSITO, FERNANDA; CERDEIRA, LOUISE; BELLO-TOLEDO, HELIA; LINCOPAN, NILTON; et al. Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals. INFECTION GENETICS AND EVOLUTION, v. 73, p. 93-97, . (16/08593-9)
SABINO, CAETANO P.; WAINWRIGHT, MARK; DOS ANJOS, CAROLINA; SELLERA, FABIO P.; BAPTISTA, MAURICIO S.; LINCOPAN, NILTON; RIBEIRO, MARTHA S.. Inactivation kinetics and lethal dose analysis of antimicrobial blue light and photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 28, p. 186-191, . (17/22406-0, 13/07937-8, 16/08593-9)
SELLERA, FABIO P.; LOPES, RALF; MONTE, DANIEL F. M.; CARDOSO, BRENDA; ESPOSITO, FERNANDA; DOS ANJOS, CAROLINA; DA SILVA, LUCIANO C. B. A.; LINCOPAN, NILTON. Genomic analysis of multidrug-resistant CTX-M-15-positive Klebsiella pneumoniae belonging to the highly successful ST15 clone isolated from a dog with chronic otitis. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 22, p. 3-pg., . (16/08593-9, 16/03044-7)
MELO, LUANA C.; ORESCO, CINTIA; LEIGUE, LUCIANNE; NETTO, HILDEBRANDO M.; MELVILLE, PRISCILLA A.; BENITES, NILSON R.; SARAS, ESTELLE; HAENNI, MARISA; LINCOPAN, NILTON; MADEC, JEAN-YVES. Prevalence and molecular features of ESBL/pAmpC-producing Enterobacteriaceae in healthy and diseased companion animals in Brazil. Veterinary Microbiology, v. 221, p. 59-66, . (16/08593-9, 13/04725-0)
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; ESPOSITO, FERNANDA; SABINO, CAETANO P.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Colistin-Resistant mcr-1-Positive Escherichia coli on Public Beaches, an Infectious Threat Emerging in Recreational Waters. Antimicrobial Agents and Chemotherapy, v. 61, n. 7, . (16/08593-9)
CASTELANI, L.; ARCARO, J. R. P.; BRAGA, J. E. P.; ROSSO, A. S.; MOURA, Q.; ESPOSITO, F.; SAUTER, I. P.; CORTEZ, M.; LINCOPAN, N.. Short communication: Activity of nisin, lipid bilayer fragments and cationic nisin-lipid nanoparticles against multidrug-resistant Staphylococcus spp. isolated from bovine mastitis. JOURNAL OF DAIRY SCIENCE, v. 102, n. 1, p. 678-683, . (16/08593-9, 13/04725-0, 13/15504-4)
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; MOURA, QUEZIA; CARVALHO, MARCELO P. N.; ROSATO, PAULA N.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Zooanthroponotic Transmission of Drug-Resistant Pseudomonas aeruginosa, Brazil. Emerging Infectious Diseases, v. 24, n. 6, p. 1160-1162, . (16/08593-9)
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