Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways

Autor(es)

Paulino, Niraldo ^{[1, 2]} ; Paulino, Amarilis Scremin ^[3] ; Diniz, Susana N. ^{[1, 2]} ; de Mendonca, Sergio ^{[1, 2]} ; Goncalves, Ivair D. ^{[1, 2]} ; Flores, Fernanda Faiao ^[4] ; Santos, Reginaldo Pereira ^{[1, 2]} ; Rodrigues, Carina ^{[1, 2]} ; Pardi, Paulo Celso ^{[1, 2]} ; Quincoces Suarez, Jose Agustin ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Anhanguera Sao Paulo UNIAN SP, Programa Posgrad Farm, Programa Mestrado Profiss Farm, Rua Maria Candida, 1813 Vila Guilherme, BR-02071013 Sao Paulo, SP - Brazil

^[2] Programa Mestrado & Doutorado Biotecnol & Inovaca, Rua Maria Candida, 1813 Vila Guilherme, BR-02071013 Sao Paulo, SP - Brazil

^[3] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Campus Univ Trindade, BR-88040400 Florianopolis, SC - Brazil

^[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Cidade Univ, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry; v. 24, n. 8, p. 1927-1935, APR 15 2016.
• Citações Web of Science: 7

Resumo

This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-{[}5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phe nolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/50435-8 - Síntese de fenóis polifuncionais e seus derivados bioativos
• Beneficiário: José Agustín Pablo Quincoces Suárez
• Modalidade de apoio: Auxílio à Pesquisa - Regular