Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

Autor(es)

da Silva, Marcelo S. ^[1] ; Pavani, Raphael S. ^[1] ; Damasceno, Jeziel D. ^[2] ; Marques, Catarina A. ^[3] ; McCulloch, Richard ^[4] ; Orsini Tosi, Luiz Ricardo ^[2] ; Elias, Maria Carolina ^[1]

Afiliação do(s) autor(es)

^[1] Butantan Inst, Ctr Toxins Immune Response & Cell Signaling CeTIC, LECC, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, Ribeirao Preto, SP - Brazil

^[3] Univ Dundee, Sch Life Sci, Div Biol Chem & Drug Discovery, Dow St, Dundee - Scotland

^[4] Univ Glasgow, Inst Infect Immun & Inflammat, Wellcome Ctr Mol Parasitol, Glasgow, Lanark - Scotland

• Tipo de documento: Artigo de Revisão
• Fonte: Trends in Parasitology; v. 33, n. 11, p. 858-874, NOV 2017.
• Citações Web of Science: 9

Resumo

In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be used in the development of chemotherapies to assist in the eradication of diseases caused by these pathogens. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/10580-0 - Caracterização de checkpoint intra-S em células de Trypanosoma
• Beneficiário: Maria Carolina Quartim Barbosa Elias Sabbaga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24170-5 - Dinâmica da replicação do DNA em Trypanosoma cruzi: caracterização do licenciamento e da taxa de replicação
• Beneficiário: Marcelo Santos da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/50050-2 - How do common and diverged features of the replicative stress response shape the biology of TriTryp parasites?
• Beneficiário: Maria Carolina Quartim Barbosa Elias Sabbaga
• Modalidade de apoio: Auxílio à Pesquisa - Temático