| Full text | |
| Author(s): |
da Silva, Marcelo S.
[1]
;
Pavani, Raphael S.
[1]
;
Damasceno, Jeziel D.
[2]
;
Marques, Catarina A.
[3]
;
McCulloch, Richard
[4]
;
Orsini Tosi, Luiz Ricardo
[2]
;
Elias, Maria Carolina
[1]
Total Authors: 7
|
| Affiliation: | [1] Butantan Inst, Ctr Toxins Immune Response & Cell Signaling CeTIC, LECC, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, Ribeirao Preto, SP - Brazil
[3] Univ Dundee, Sch Life Sci, Div Biol Chem & Drug Discovery, Dow St, Dundee - Scotland
[4] Univ Glasgow, Inst Infect Immun & Inflammat, Wellcome Ctr Mol Parasitol, Glasgow, Lanark - Scotland
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | Trends in Parasitology; v. 33, n. 11, p. 858-874, NOV 2017. |
| Web of Science Citations: | 9 |
| Abstract | |
In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be used in the development of chemotherapies to assist in the eradication of diseases caused by these pathogens. (AU) | |
| FAPESP's process: | 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 15/10580-0 - Characterization of intra-S checkpoint in Trypanosoma cells |
| Grantee: | Maria Carolina Quartim Barbosa Elias Sabbaga |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/24170-5 - DNA replication dynamics in Trypanosoma cruzi: licensing and replication rate characterization |
| Grantee: | Marcelo Santos da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/50050-2 - How do common and diverged features of the replicative stress response shape the biology of TriTryp parasites? |
| Grantee: | Maria Carolina Quartim Barbosa Elias Sabbaga |
| Support Opportunities: | Research Projects - Thematic Grants |