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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review

Texto completo
Autor(es):
Pires Borges, Isabela Bruna [1] ; Silva, Marilda Guimares [1] ; Misse, Rafael Giovane [1] ; Shinjo, Samuel Katsuyuki [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: RHEUMATOLOGY INTERNATIONAL; v. 38, n. 2, p. 293-301, FEB 2018.
Citações Web of Science: 6
Resumo

Lipid-lowering agent-triggered dermatomyositis (DM) or polymyositis (PM) is a rare event. Therefore, the aim of the present study was to describe a series of such cases. A retrospective cohort study of 5 DM and 4 PM cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. All patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-SRP or anti-HMGCoAR. Median age of the patients at time of diagnosis was 68 years. Seven patients had previously taken simvastatin 20 mg/day (exposure period from 2 days to 4 years) and two bezafibrate 100 mg/day (3-4 months). Median time from symptom onset to disease diagnosis was 6 months. All patients with DM had a heliotrope and/or Gottron's papules. All patients had symmetrical, predominantly proximal muscle weakness of limbs, with median serum creatine phosphokinase of 3087U/L (interquartile 25-75% range 1293-13,937 U/L). All patients received glucocorticoid and immunosuppressants. Complete reversal of clinical symptoms and normalization of serum creatine phosphokinase level occurred within a median of 12 months after starting the treatment. There was disease relapse in three cases, and one case of death was unrelated to the disease (pulmonary infectious complications resulting from lymphoma). In contrast to cases described in the literature, the patients in the present study had a relatively more aggressive course, requiring glucocorticoids and immunosuppressants, in addition to a tendency for a longer period to achieve disease remission. (AU)

Processo FAPESP: 16/23574-0 - Efeitos do treinamento físico na função endotelial e nas propriedades funcionais de grandes artérias de pacientes com miopatias inflamatórias idiopáticas: Ensaio clínico controlado e randomizado
Beneficiário:Rafael Giovani Misse
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 15/12628-0 - Caracterização do autoanticorpo anti-melanoma differentiation associated gene 5 (anti-MDA5) em pacientes com dermatomiosite e polimiosite
Beneficiário:Isabela Bruna Pires Borges
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 14/09079-1 - Impacto de corticoterapia no processo inflamatório de biópsia muscular de dermatomiosite e polimiosite
Beneficiário:Samuel Katsuyuki Shinjo
Linha de fomento: Auxílio à Pesquisa - Regular